Lewis-Sumner syndrome (LSS) is a dysimmune peripheral nerve disorder, characterized by a predominantly distal, asymmetric weakness mostly affecting the upper limbs with sensory impairment, and by the presence of multifocal persistent conduction blocks. The nosological position of this neuropathy in relation to multifocal motor neuropathy (MMN) and chronic inflammatory demyelinating polyradiculo...

AIM To compare different method(s) to detect peripheral neuropathy in leprosy and to study the validity of the monofilament test (MF) and the voluntary muscle test (VMT) as standard tests of nerve function. DESIGN A multi-centre cohort study of 303 multibacillary (MB) leprosy patients. METHODS Newly registered MB patients requiring a full course of MDT were recruited in two leprosy outpatie...

Pathophysiological changes in sensory fibres in chronic acquired demyelinating neuropathy (CADP) are poorly understood, and it is not known to what extent sensory loss may be due to axonal loss or to conduction block. Motor and sensory nerve condition were studied in 18 patients with CADP to delineate abnormalities in the compound sensory action potential (CSAP) recorded proximally along the li...

The motor Nerve conduction studieswas done in CPN (common peroneal nerve) in fifty healthy male and female subject, 16-20 year of age. The values were establish for comparisons and references. The Amplitude of motor and were divided into different components and computerized machine was used to analyze the DL, Amplitude and conduction velocities. The CPN Motor studies gave DL of 4.09 ms, Amplid...

this report describes a 55-year-old woman in whom yellow scorpion sting resulted in the development of mobitz type 1 and transient complete heart blocks unresponsive to atropine administration.  it might be concluded that although autonomic involvement including parasympathetic overactivity is present in such cases, other factors such as toxic damage to the cardiac conduction system may play a ...

BACKGROUND 3,4-diaminopyridine (3,4-DAP), a potassium (K+) channel blocker, improves fatigue and motor function in multiple sclerosis (MS). Although it was thought to do so by restoring conduction to demyelinated axons, recent experimental data show that aminopyridines administered at clinical doses potentiate synaptic transmission. OBJECTIVE To investigate motor cerebral activity with fMRI a...