in the present study, the effects of pregnant nmri mice restraint stress on the responsibility of their children to the behavioral properties of morphine, sulpiride and dextromethorphan were investigated in the f2 generation. twenty four pregnant nmri female mice (w: 25 g) were divided into the experimental and control groups (n = 12/group). animals in the experimental group were kept in the re...

Phenotypes that are either resistant or susceptible to infection by the trematode parasite Schistosoma mansoni exist in the tropical freshwater snail Biomphalaria glabrata. We tested the hypothesis that a cost of parasite resistance in B. glabrata is greater sensitivity to cadmium toxicity, using parasite-resistant and parasite-susceptible strains exposed to cadmium in the laboratory. Survival ...

The highly mutagenic heterocyclic amines, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), are formed during heating of protein-rich foods. In order to gain information about the distribution and fate of IQ and MeIQ in vivo, a whole-body autoradiographic study of i.v.-injected 14C-labeled IQ and MeIQ has been performed in male NMRI, pregnant N...

Background: Depression is an important psychological disorder because it a common mental illness that leads to morbidity and suicide. Although appropriate antidepressant drugs exist, they usually have unpleasant side effects delayed onset. Objectives: Introducing new compounds such as medicinal plants oceanic living organisms alga appropriate. Here the depressive-like of Padina australis Hauck ...

background: this investigation aimed to evaluate the in vitro scolicidal effects of pistacia khinjuk methanolic extract against protoscoleces of hydatid cysts and its acute toxicity in mice nmri model. methods: protoscoleces were aseptically extracted from sheep livers having hydatid cysts. various concentrations of the essential oil (12.5- 100 mg/ml) were used for 10 to 60 min. viability of pr...

background: in some disorders such as diabetes mellitus patients can display depressive symptoms. metformin is among the first-line treatments for management of the type 2 diabetes mellitus which may have some anti-depressant effect. objective: current investigation was performed to examine the anti-depressant effects of metformin and the involvement of nitric oxide (no) in this way, in an expe...