Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa which is considered by the World Health Organization (WHO) as a premalignant condition. One step in malignant development is so called epithelial mesenchymal transition (EMT), a process whereby epithelial cells acquire mesenchymal characteristics. A factor known to induce EMT is the transforming growth factor-β (TGF-β...

Lichen planus is a T-cell mediated autoimmune disorder affecting the skin and mucous membranes. Ulcerating lichen planus is uncommon mostly on oral and genital mucosa but not skin. Lichen planopilaris, however, is a subtype of lichen planus affection hair follicles and leading to permanent scarring alopecia. We report a case of lichen planopilaris of the scalp with multiple alopecic patches ulc...

background: proliferating cell nuclear antigen (pcna) is a nuclear protein synthesized in the late g1 and s-phase of the cell cycle. detection of this protein represents a useful marker of the proliferation status of lesions. this study has been carried out to evaluate the cell proliferation rate in oral lichen planus (olp) and comparison between plaque and erosive lichen planus, which indicate...

introdouction: lichen planus is a chronic, relatively common, dermal mucosa disease. the world health organization (who) has introduced lichen planus as a premalignant condition. ki-67 is a protein that can be detected in all active phases of the cell cycle, especially in the g2 and m phases. considering the major role of ki-67 in the regulation of the cell cycle and the fact that it is one of ...

Introduction: Lichen planus is an inflammatory mucocutaneous disease that its etiology is still unknown. Various treatments are used to mitigate the pain, inflammation, and duration of lesions. Due to the lack of a definitive treatment and the side effects of current treatments, many efforts still have been making to find new treatments. As curcumin has been shown to have anti-inflammatory, an...

OBJECTIVES Current treatments of oral lichen planus are palliative, not curative. Because psychiatric disorders significantly influence the development and severity of oral lichen planus, the use of psychiatric drug therapy may be an adjunct in treatment. The purpose of this study was to determine the efficacy of drug therapy of psychiatric disorders in oral lichen planus. STUDY DESIGN Our co...

Background and Aim: Lichen planus is an inflammatory autoimmune mucocutaneous disease. Stimulation of T cells and antigen-presenting cells (APCs), such as dendritic cells, mediates apoptosis of keratinocytes and basement membrane destruction. The aim of this study was to investigate the expression of one of the immune cell markers (CD86) in erosive oral lichen planus. Materials and Methods: In...

Stress is defined as a physical, mental or emotional response to events that causes bodily or mental tension. Every organ in the human body is affected by various types of diseases like infection caused by microbes, immunological, metabolic, endocrinal disturbances etc., Etiopathogenesis of many diseases are discovered and managed at any early stage, still some diseases are considered as idiopa...