the molecular basis of metastatic potential of human breast carcinoma cells can be useful information to determine the practical implications in the diagnosis, determining prognosis and treatment of breast cancer. the aim of this study was to identify predictors of aggressive biological behavior and metastatic potential in breast carcinoma among a number of intrinsic biomarkers of tumor cells. ...

Introduction: Diabetes is associated with an increased risk of cancer. Because of the metastatic nature of cancer, the survival of women with breast cancer is decreasing despite receiving various treatments such as chemotherapy, radiotherapy, etc. The aim of this study was to investigate the relationship between diabetes and the risk factors related to the survival of breast cancer patients. M...

background: molecular biomarkers are valuable in evaluation the course of malignancies. in this study, the relationship be­tween her2/neu, p53, steroid receptors and clinicopathological features of patients with breast cancer has been assessed. methods : three hundred thirty nine women with a primary diagnosis of breast cancer from 2001 to 2006 were included. they were evaluated for tumor featu...

objective: rna interference (rnai) is the most potent technique for gene silencing in eukaryotic cellular system at transcriptomic level. genetic disorders and cancers are important targets for therapeutic development of this technique. in order to bypass the temporary dpwnregulation by sirna, a new generation of shrna named shrnamir has developed. silencing construct with structure similar to ...

Abstract Introduction Sigma receptors (SRs) are regularly overexpressed in cancer however their functions remain unknown. Certain Sigma1-receptor (Sig1R) ligands trigger death breast (BCa) cells but not non-cancerous (NCB). In stressed cells, Sig1R is vital to the pro-survival unfolded protein response (UPR). Cancer depend on UPR signalling for survival, investigating mediated mechanisms BCa vs...

In recent years, the potential of marine natural products as anticancer agents, specifically for breast cancer, has been examined. The sea cucumber (Holothuroidea: Echinodermata) is known to contain triterpene glycosides, which have shown anticancer or cytotoxic activity. In this research, molecular docking of selected sea cucumber bioactive compounds was conducted on five receptor targets that...

Curcumin exhibits both cancer- preventive activity and growth inhibitory effects on several neoplastic cells including human colon cancer. Serotonin and its receptors have also been implicated in tumor development. This study investigated the effect of ritanserin, a selective serotonin 5HT2A receptor antagonist, alone and in combination with curcumin on colorectal cancer cell lines. Result...

Expression of adhesion receptor integrin v 3 in an activated functional form strongly promotes metastasis in human breast cancer cells. Here, we report that v 3 cooperates with matrix metalloproteinase type 9 (MMP-9) in breast cancer cell migration. This cooperation is regulated by the activation state of the integrin. Expression of activated v 3 in metastatic variants of MDA-MB 435 human breas...