Prolonged seizures may alter the brain function in numerous ways. It is conceivable that they might lead to modifications of seizure susceptibility or anticonvulsive drug efficacy, however, only limited data address this issue. Therefore, we have decided to estimate the antiepileptic activity of drugs interfering with GABA-ergic neurotransmission in mice subjected to prolonged clonic seizures 2...

Conventional treatment for cancer such as surgical resection and chemotherapy can cause damage in cases with advanced cancers. Moreover, the identification of tumor-specific targets has great importance in T-cell therapies. For decades, T cell activity has been stimulated to improve anti-tumor activity. Bispecific antibodies have attracted strong interest from pharmaceutical companies, for thei...

BACKGROUND Status epilepticus (SE) is a serious neurological condition and requires prompt treatment. Sodium valproate has been used to treat SE successfully but its role as the first-line antiepileptic drug (AED) is still controversial. This study evaluated the efficacy of intravenous sodium valproate to determine if it is non-inferior to intravenous phenytoin in SE treatment. METHODS Patien...

The present study was undertaken to provide more information on nucleolar changes induced by a histone deacetylase inhibitor such as valproic acid in leukaemic myeloblasts at the single-cell level. For this study, RNA in nucleoli was visualized by a simple but sensitive cytochemical procedure in unfixed cytospins of short-term bone marrow cultures from patients suffering from acute myeloid leuk...

The vaporization enthalpy of valproic acid (2-propylpentanoic acid) is reported, and the vapor pressures of a series on aliphatic carboxylic acids are used to evaluate its vapor pressure as a function of temperature. The vaporization enthalpy was derived by correlation-gas chromatography. This resulted in a vaporization enthalpy, ΔHvap(298.15 K) of (74.8 ± 2.4) kJ·mol−1. Vapor pressures from T/...

OBJECTIVE To determine whether patients who fail their first antiepileptic drug (AED) have better neuropsychiatric and quality-of-life (QOL) outcomes if substituted to levetiracetam monotherapy compared with a second older AED. DESIGN Randomized comparative trial. Participants with partial epilepsy who had failed monotherapy with phenytoin sodium, carbamazepine, or valproate sodium were randomi...

BACKGROUND Numerous studies have shown that long term treatment with anticonvulsants may be an important risk factor for the onset of atherosclerosis, or worsening of its symptoms. There are many contradictory reports regarding these effects. OBJECTIVES We performed a systematic review and meta-analysis of the published studies in order to see whether the atherogenic outcomes could be related...

background: status epilepticus (se) is a type of persistent lasting seizure with high mortality and morbidity. numerous medications are suggested for the treatment of se, two of which are sodium valproate and phenytoin. the purpose of this study is to conduct a comparison between the effi ciencies of intravenous sodium valproate and phenytoin in the treatment of this type of epilepsy. methods: ...

The risk of having a baby with a neural tube defect (NTD) for women taking sodium valproate (VPA) is about 2%1, or at least 60 times the background risk in the UK. Since this is similar to that for recurrence of a NTD in someone who has previously had a baby with this condition, for whom high-dose periconceptual folic acid (4 mgs/day) is known to offer considerable protection2, it has been sugg...