Spatial networks, also known as random geometric graphs, are random graphs with certain distance metric, in which each node is connected to some others within its neighborhood disc. Due to the rapid increase of network scales, the design of spatial networks becomes increasingly challenging. Inspired by the recently discovered small-world topology in relational networks, we identify an efficient...

The spatial organization of transmembrane receptors is a critical step in signal transduction and receptor trafficking in cells. Transmembrane receptors engage in lateral homotypic and heterotypic cis-interactions as well as intercellular trans-interactions that result in the formation of signalling foci for the initiation of different signalling networks. Several aspects of ligand-induced rece...

As synthetic pathways built from exogenous enzymes become more complicated, the probability of encountering undesired interactions with host organisms increases, thereby lowering product titer. An emerging strategy to combat this problem is to spatially organize pathway enzymes into multi-protein complexes, where high local concentrations of enzymes and metabolites may enhance flux and limit pr...

Spatial hypertext systems use physical properties as color, dimensions, and position to represent relationships between documents. These systems allows the user to express a lot of different relationships between information but the structure should be build by hand by the user. This can be complex if a large number of information is involved. Self-organizing neural networks map can automatical...

The dynamic behavior of microtubules in solution can be strongly modified by interactions with walls or other structures. We examine here a microtubule growth model where the increase in size of the plus-end is perturbed by collisions with other microtubules. We show that such a simple mechanism of constrained growth can induce ordered structures and patterns from an initially isotropic and hom...

Since the early days of light microscopy it has been apparent that cells are highly organized and compartmentalized. However, only in recent decades has the molecular basis of this spatial organization and its functional role in cellular signalling events emerged. Furthermore, modern molecular and imaging techniques, together with the intricate combination of cellular and developmental biologic...

The effects of increased mortality on the spatial dynamics of solitary carnivores are not well understood. We examined the spatial ecology of two cougar populations that differed in hunting intensity to test whether increased mortality affected home range size and overlap. The stability hypothesis predicts that home range size and overlap will be similar for both sexes among the two areas. The ...

Urban Dynamics modeling needs to implement spatial organization emergence in order to describe the development of services evolution and their usage within spatial centers. In this paper, we propose an extension of the nest building algorithm with multi-center, multi-criteria and adaptive processes. We combine a decentralized approach based on emergent clustering mixed with spatial constraints ...

The manner by which eukaryotic genomes are packaged into nuclei while maintaining crucial nuclear functions remains one of the fundamental mysteries in biology. Over the last ten years, we have witnessed rapid advances in both microscopic and nucleic acid-based approaches to map genome architecture, and the application of these approaches to the dissection of higher-order chromosomal structures...