The effect of naloxone, a non-selective opioid antagonist on some anxiolytic and analgesic drugs is reported. Noscapine is an opioid alkaloid with antitussive effect that cannot be antagonized by naloxone. The anxiolytic-like effect of noscapine has been shown in light-dark model and elevated plus maze. In this study the effect of naloxone on anxiolytic effect of noscapine in light-dark model w...

Aging has negative effects on motor and cognitive functions, therefore finding appropriate strategies to prevent the decline of these functions is necessary. It seems that cardiovascular fitness obtained by aerobic activity is a physiological mediator that explains the relationship between physical activity and improved cognitive performance. The aim of this research was to assess the effect...

Motivated by applications in ride-sharing and truck-delivery, we study the problem of matching a number requests assigning them to cars. A cars are given, each which consists location speed, pick-up drop-off location. Serving request means that car must first visit then Each can only serve at most c requests. assignment yield multiple different serving routes corresponding times, our goal was m...

materials and methods in this experimental study, nmri male mice were placed in groups receiving atropine (0.1 and 1 mg/kg), recipient of mgo-n (1, 2.5, and 5 mg/kg) and groups receiving atropine in effective dose and different doses of mgo-n were used. saline was used as a vehicle for drugs in the control groups. memory was evaluated with a step-down apparatus to determine the coming down late...

Studies from a wide diversity of taxa have shown a negative relationship between genetic compatibility and the divergence time of hybridizing genomes. Theory predicts the main breakdown of fitness to happen after the F1 hybrid generation, when heterosis subsides and recessive allelic (Dobzhansky-Muller) incompatibilities are increasingly unmasked. We measured the fitness of F2 hybrids of Africa...

Recent studies have suggested that physiological and behavioral traits may be transgenerationally inherited through the paternal lineage, possibly via non-genomic signals derived from the sperm. To investigate how paternal stress might influence offspring behavioral phenotypes, a model of hypothalamic-pituitary-adrenal (HPA) axis dysregulation was used. Male breeders were administered water sup...