Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits.    Plasma concentration of both 5-FU and its metabolit...

Estimating (co)variance parameters of a random regression model for test day yields of dairy cattle has been proven to be a challenging task due to the complexity of (co)variance structure of the test day yields. Two common approaches have been practised so far for the estimation of parameters: direct random regression model approach and indirect covariance functions (CF) approach. Animal genet...

The aim of this study was to estimate genetic parameters for female fertility and production traits in first-parity Czech Holstein cows and to quantify the effect of using this information on the accuracy of a selection index in seven different scenarios. In order to estimate genetic (co)variance components, the DMU software running an AI-REML algorithm was used. The analyses were made using a ...

Test-day variances for permanent environmental effects within and across parities were estimated along with lactation stage, age, and pregnancy effects for use with a test-day model. Data were test-day records for calvings since 1990 for Jerseys and for Holsteins from California, Pennsylvania, Texas, and Wisconsin. Single-trait repeatability models were fitted for milk, fat, and protein test-da...

introduction: lactation yield and persistency are two economic important traits in dairy cow. the production level of a dairy cow is determined by a joint effect of genetic and environmental factors.the main factors determining the total amount of milk production are milk yield at the peak of lactation and persistency as well as length of lactation period. persistency are defined as a extent to...

An international collaborative study involving 14 collaborators from 5 different countries was conducted to test a rapid liquid chromatographic (LC) method for detecting aflatoxins M1 and M2 in fluid milk. Each collaborator prepared artificially contaminated milk samples (0.078-1.31 ng M1/mL and 0.030-0.13 ng M2/mL) by adding solutions containing various concentrations of aflatoxins M1 and M2 t...