Doxorubicin (DOX) is an anthracycline antibiotic with broad spectrum anti-tumour activity. Its effectiveness has been limited by the occurrence of dose-related myocardial and bone marrow toxicity. As oxidative stress is the main factor in DOX-induced cardiotoxicity, we presumed that agents which enhance endogenous antioxidants can prevent DOX induced cardiotoxicity. Animals received either DOX ...

Objective(s): Cerebral ischemia/reperfusion causes complex pathological mechanisms that lead to brain tissue damage. Usnic acid is a lichen secondary metabolite that has many different biological properties including anti-inflammatory and anti-oxidant activities. Therefore, the objective of the current study was to investigate the neuroprotective effects of usnic acid ...

BACKGROUND The fermented leaves and stems of Cyclopia intermedia are used to brew honeybush tea, a herbal tea indigenous to South Africa. The aim of this study was to evaluate the protective effect of fermented honeybush extracts (FH ex) and scale-up fermented honeybush extracts (SFH ex) against ultraviolet B (UVB)-induced damage in HaCaT keratinocytes. To this end, we examined UVB-induced cell...

1. The activities of the oxidative enzymes (glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase) and of the non-oxidative enzymes (transaldolase, tranketolase, ribose 5 phosphate isomerase and ribulose 5-phosphate 3-epimerase) of the pentose phosphate pathway were measured at various times during the first 24h of skeletal-muscle regeneration after administration of Marcaine, ...

the present study was designed to investigate the protective effect of ethanol extracts from lindera coreana leaves (lce) on uvb-induced oxidative stress in hacat keratinocytes. the hacat cells were pretreated with lce for 24 h and then exposed to uvb (20 mj/cm2) for 2 h. uvb significantly decreased the cell viability (p<0.05). lce did not exhibit significantly cytotoxic effects and increased t...

Nanotechnologies promise new means for drug delivery. ICAM-1 is a good target for vascular immunotargeting of nanoparticles to the perturbed endothelium, although endothelial cells do not internalize monomeric anti-ICAM-1 antibodies. However, coupling ICAM-1 antibodies to nanoparticles creates multivalent ligands that enter cells via an amiloride-sensitive endocytic pathway that does not requir...

Objective: Chronic ethanol consumption has significant negative effects on liver tissue. Mechanisms of ethanol toxicity include oxidative stress and inflammation. The antioxidant and anti-inflammatory properties of the lemon verbena have been proven in studies. The aim of this study was to evaluate the protective effect of hydro alcoholic extract of Aloysia citriodora (AC) on ethanol-induced he...

In a complex enzymatic sequence the site of action of substrates and inhibitors is clearly marked by the way they affect the steady state concentrations of the components of the system (1). Antimycin A, for example, inhibits respiration in the succinic oxidase system (2) and at the same time increases the steady state reduction of cytochrome b and decreases that of cytochromes c, a, and aa (3)....