The effect of changes in cellular iron metabolism on the surface expression of transferrin receptors (TfR) was examined in primary cultures of hepatocytes from adult rats. Untreated control hepatocytes exhibited a single class of high affinity receptors for transferrin (KD = 40 nM), with approximately 17,000-18,000 receptors per cell. Following 24 h of treatment with the iron chelator, desferri...

The cell infection processes and host ranges of canine parvovirus (CPV) and feline panleukopenia virus (FPV) are controlled by their capsid interactions with the transferrin receptors (TfR) on their host cells. Here, we expressed the ectodomains of wild-type and mutant TfR and tested those for binding to purified viral capsids and showed that different naturally variant strains of the viruses w...

T follicular regulatory (Tfr) cells are a subset of Foxp3(+) regulatory T (Treg) cells that form in response to immunization or infection, which localize to the germinal centre where they control the magnitude of the response. Despite an increased interest in the role of Tfr cells in humoral immunity, many fundamental aspects of their biology remain unknown, including whether they recognize sel...

We have calculated two new sets of weights applicable to the General Household Survey (GHS) from 1979 to 2007. One of these is for use with any general analysis of GHS topics and the second is designed for analyses of data collected in the Family Information section. The methods used follow closely those employed by ONS from 1996 onwards. The performance of the weights is assessed in estimating...

We compare two methods of distance determination to spiral galaxies using optical/near-infrared (NIR) observations, the (I–K) versus MK colour – absolute magnitude (CM) relation and the I and K-band Tully-Fisher relation (TFR). Dust-free colours and NIR absolute magnitudes greatly enhance the usefulness of the NIR CM relation as a distance indicator for moderately to highly inclined spiral gala...

The objective of the study was to evaluate the diagnostic efficiency of laboratory tests, including serum transferrin receptor (TfR) measurements, in the diagnosis of iron depletion. The patient population consisted of 129 consecutive anemic patients at the University Hospital of Turku who were given a bone marrow examination. Of these patients, 48 had iron deficiency anemia (IDA), 64 anemia of...

Recent studies showed that gallium and iron uptake are decreased in gallium-resistant (R) CCRF-CEM cells; however, the mechanisms involved were not fully elucidated. In the present study, we compared the cellular uptake of 59Fe-transferrin (Tf) and 59Fe-pyridoxal isonicotinoyl hydrazone (PIH) to determine whether the decrease in iron uptake by R cells is caused by changes in Tf receptor (TfR)-d...