نتایج جستجو برای: direct macrocyclization
تعداد نتایج: 425220 فیلتر نتایج به سال:
The first synthesis of dolabelide C (1), a cytotoxic marine macrolide, is reported utilizing a phosphate tether-mediated approach. Bicyclic phosphates (S,S,S(P))-5 and (R,R,R(P))-5 serve as the central building blocks for the construction of two major 1,3-anti-diol subunits in 1 through selective cleavage pathways, regioselective olefin reduction, and cross-metathesis. Overall, phosphate-mediat...
The synthesis of the macrolactone core of (+)-neopeltolide has been achieved. The key synthetic strategy involves the highly diastereoselective synthesis of the 2,6-cis-disubstituted tetrahydropyran ring by a transannular cyclization of δ-hydroxy alkene using mercuric trifluoroacetate. Two of the six stereocenters C-5 and C-11 were realized from L-malic acid, while the remaining stereocenters C...
ددر این تحقیق استفاده از کربن اکتیو ، ذرات نانو مغناطیسی آهن و ذرات نانو کامپوزیت آهن- کربن اکتیو، برای حذف رنگ آنیونی از پسابهای سمی مورد مطالعه قرار گرفتند . رنگ direct orange -26 به عنوان مدلی از رنگ آنیونی مورد بررسی قرار گرفت. مشخصات سطحی نانو ذرات آهن و نانو کامپوزیت آهن توسط sem مورد بررسی قرار گرفت . تاثیر عوامل مختلف (ph ، دوز جاذب، زمان تماس، دور هم زدن) به روش طراحی آزمایش تاگوچی مور...
rested on sociocultural theory (sct), this study attempted to examine the effect of written corrective feedback (wcf) followed by producing written languaging on developing writing accuracy over new tasks. to this aim, two intact iranian efl classes at the low-intermediate level were randomly assigned to two experimental groups: direct (n = 25) and indirect (n = 25). both groups wrote on a numb...
current studies in second language (l2) learning have revealed the positive role of corrective feedback (cf) in both oral and written forms in different language features. the present study was an attempt to investigate the effect of both direct and indirect written corrective feedback (wcf) on the use of grammatical collocations in l2 writing. the study also sought to examine whether the effec...
We report a double-click macrocyclization approach for the design of constrained peptide inhibitors having non-helical or extended conformations. Our targets are the tankyrase proteins (TNKS), poly(ADP-ribose) polymerases (PARP) that regulate Wnt signaling by targeting Axin for degradation. TNKS are deregulated in many different cancer types, and inhibition of TNKS therefore represents an attra...
Abstract Cyanopyridylalanines are non‐canonical amino acids that react with aminothiol compounds under physiological conditions in a biocompatible manner without requiring added catalyst. Here we present newly developed aminoacyl‐tRNA synthetases for genetic encoding of meta ‐ and para ‐cyanopyridylalanine to enable the site‐specific attachment wide range different functionalities. The outstand...
Herein, we report the synthesis and investigation of a substituted [10]cycloparaphenylene (CPP) incorporating diethylphthalane unit. An efficient strategy relying on symmetric built-up starting with propargyl ether as [2+2+2] cycloaddition precursor was developed. The straightforward required overcoming unexpected obstacles within cycloaddition, protection aromatization. These results give valu...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید