The effect of workflow interference is a major concern in facility layout design. Yet, despite the extensive amount of research conducted on the facility layout problem, very little has been done to incorporate interference as part of an overall approach to layout design. This paper examines the impact of workflow interference considerations on facility layout analyses. Linear and nonlinear int...

P2Y(12) receptor antagonists are antithrombotic agents that inhibit platelet function by blocking the effects of adenosine diphosphate (ADP) at P2Y (12)receptors. However, some P2Y(12) receptor antagonists may affect platelet function through additional mechanisms. It was the objective of this study to investigate the possibility that P2Y(12) antagonists inhibit platelet function through intera...

Aggregation functions are widely used in answer set programming for representing and reasoning on knowledge involving sets of objects collectively. Current implementations simplify the structure of programs in order to optimize the overall performance. In particular, aggregates are rewritten into simpler forms known as monotone aggregates. Since the evaluation of normal programs with monotone a...

the scarcity of water resources and supply resources limitation, have caused an increasing gap between water supply and demand specially in recent decades in almost all regions of the globe. one of the best known solutions proposed by the economists is using the different water pricing approaches thereby obtaining the optimal allocation and social justice. to this purpose, this paper uses the p...

Several fuzzy connectives, including those proposed by Lotfi Zadeh, can be seen as linear extensions of the Boolean connectives from the scale ${0,1}$ into the scale $[0,1]$. We discuss these extensions, in particular, we focus on the dualities arising from the Boolean dualities. These dualities allow to transfer the results from some particular class of extended Boolean functions, e.g., from c...

We examine various aspects of modeling and solution via mixedinteger nonlinear programming (MINLP). MINLP has much to offer as a powerful modeling paradigm. Recently, significant advances have been made in MINLP solution software. To fully realize the power of MINLP to solve complex business optimization problems, we need to develop knowledge and expertise concerning MINLP modeling and solution...

In this paper, we integrate goal programming (GP), Taylor Series, Kuhn-Tucker conditions and Penalty Function approaches to solve linear fractional bi-level programming (LFBLP)problems. As we know, the Taylor Series is having the property of transforming fractional functions to a polynomial. In the present article by Taylor Series we obtain polynomial objective functions which are equivalent...

Connected Facility Location (ConFL) is a problem that combines network design and facility location aspects: given a set of customers, a set of potential facility locations and some inter-connection nodes, ConFL searches for the minimum-cost way of assigning each customer to exactly one open facility, and connecting the open facilities via a Steiner tree. The costs needed for building the Stein...

In this research, a single batch processing machine scheduling problem with minimization of total earliness and tardiness as the objective function is investigated.We first formulate the problem as a mixed integer linear programming model. Since the research problem is shown to be NP-hard, an improved memetic algorithmis proposed to efficiently solve the problem. To further enhance the memetic ...