Drug-induced cholestasis is the main type of liver disorder accompanied by high morbidity and mortality. Evidence for the role of hepatobiliary pumps in the cholestasis patho-mechanism is constantly increasing. Recognition of the interactions of chemical agents with these transporters at the initial phases of drug discovery can help develop new drug candidates with low cholestasis potential. Th...

recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. to evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. the polymorphisms of genes encoding carcinogen-metabolizing ...

Drug-induced cholestasis is the main type of liver disorder accompanied by high morbidity and mortality. Evidence for the role of hepatobiliary pumps in the cholestasis patho-mechanism is constantly increasing. Recognition of the interactions of chemical agents with these transporters at the initial phases of drug discovery can help develop new drug candidates with low cholestasis potential. Th...

Appropriate scheduling and sequencing of tasks on machines is one of the basic and significant problems that a shop or a factory manager encounters with it, this is why in recent decades extensive researches have been done on scheduling issues. A type of scheduling problems is just-in-time (JIT) scheduling and in this area, motivated by JIT manufacturing, this study investigates a mathematical ...

to estimate heritability and genetic trend for 305-d milk production and lactation persistency, a total of 130,668 monthly test day milk yields belonging to 15,183 first lactation holstein cows in 131 herds and calved from 2000 to 2009 were used. to calculate 305-d milk yield as well as lactation persistency, estimated parameters of wilmink’s exponential function were applied. the parameters of...

In Evaluating Performance, Selecting a Subset from a Set of Solutions with Limited Resources is Essential. If There Is More Than One Input and Output, the Data Rnvelopment Analysis Optimization Models Are Evaluated and Performance Measurement Based on the Weighted Output Is Divided Weighted Input. In This Research, Two Models of Optimization with Limited Resources Present from Data Envelopment ...

Abstract: Urban canyon is categorized as hard environment for positioning of a dynamic vehicle due to low number and also bad configuration of in-view satellites. In this paper, a tuning procedure is proposed to adjust the important factors in Kalman Filter (KF) using Genetic Algorithm (GA). The authors tested the algorithm on a dynamic vehicle in an urban canyon with hard condition and compare...

Appropriate scheduling and sequencing of tasks on machines is one of the basic and significant problems that a shop or a factory manager encounters; this is why in recent decades extensive studies have been done on scheduling issues. One type of scheduling problems is just-in-time (JIT) scheduling and in this area, motivated by JIT manufacturing, this study investigates a mathematical model for...

Conversational feedback is mostly performed through short utterances such as yeah, mhmm, okay not produced by the main speaker but by one of the other participants of a conversation. Such utterances are among the most frequent in conversational data. They also have been described in psycho-linguistic models of communication as a crucial communicative tool for achieving coordination or alignment...