It is over several decades that ultrasound is used to enhance the transdermal drug delivery (phonphoresis). The mechanism of the enhancement is not fully understood and the ability of ultrasound on the enhancement for some drugs is unclear. The effect of continuous wave 870 KHz ultrasound at intensity of 1 W/cm 2 for 15 minutes on transdermal absorption of piroxicam from solution and gel formu...

In this paper we report the design, synthesis, antinociceptive and anti-inflammatory activities of a series of benzothiazine N-acylhydrazones 14a–h, planned by structural modification of piroxicam (1), a non steroidal anti-inflammatory drug. Among the synthesized analogues, compounds 14f (LASSBio-1637) and 14g (LASSBio-1639) were identified as novel antinociceptive and anti-inflammatory prototy...

Rifampicin is known to influence the metabolic disposition of other drugs because of its 'enzyme inducing' effects in the liver (1, 6). The microsomal enzymes catalyze glucuronide conjugations and most of the oxidation of the drugs. Reduction and hydrolysis of drugs are catalyzed by both microsomal and non-microsomal enzymes (3). Hydroxylation and glucuronide formation are involved in the metab...

The purpose of the present study was to investigate the contribution of prostaglandins (PGs) synthesized by constitutive (COX-1) and inducible (COX-2) cyclooxygenase to stimulation of the hypothalamic-pituitary-adrenal (HPA) axis by adrenergic receptor agonists in rats under social crowing stress 3 days, (21 per a cage for 6) animals. The effects of phenylephrine, clonidine and isoprenaline, an...

Objective: The main purpose of this study was to evaluate the effects of virgin olive oil phonophoresis on female athletes' anterior knee pain (AKP). Materials and Methods: A double blinded randomized clinical trial was conducted. Ninety-three female athletes suffering from AKP voluntarily participated in this study. Patients were randomly assigned into olive oil (n=31), piroxicam (n=31) or bas...

The main focus of the work was to develop a hydrogel carboxy methyl cellulose tailored dextran containing piroxicam intended for transdermal delivery. Firstly, formulated by conjugation with amino and then mixed encapsulation in matrix. characterization performed terms zeta potential, entrapment efficiency, morphology vitro drug release. size particles found 134 nm cellulose-dextran hydrogels e...

The mechanisms by which cyclooxygenase inhibitors exert antitumor effects are not completely defined but are postulated to involve antiangiogenic effects and induction of apoptosis. In this study, we determined the effects of the cox inhibitor, piroxicam, on tumor response, apoptotic index, proliferative index, cyclooxygenase-2 expression, prostaglandin E(2) concentration, tumor microvessel den...