OBJECTIVES To evaluate the use of Cinryze (nanofiltered C1-esterase inhibitor [C1 INH-nf]) for the acute management and prevention of hereditary angioedema attacks in the subgroup of children and adolescents who participated in 2 placebo-controlled and 2 open-label extension studies. STUDY DESIGN In the acute-attack treatment studies, the efficacy of 1000 U of C1 INH-nf (with an additional 10...

Pressure relief valves and vents in the petrochemical industry are often the last line of defense in averting a major accident. Recent design standards (API 520/521) have been developed which have reduced the recommended exit velocities for hydrocarbons from pressurized storage. There are computer models available which predict the release and dispersion of high velocity gas jets. In some insta...

BACKGROUND Labour analgesia has rapidly gained popularity in obstetric practice. Low usage in the developing world has raised concern. OBJECTIVES To assess the knowledge, attitude and use of labour pain relief methods in women attending antenatal clinic in Nairobi. DESIGN A prospective study. SETTING Aga Khan University Hospital, a teaching and referral hospital in Nairobi, Kenya. SUBJE...

BACKGROUND Technological advances during the last few decades have improved the success rate of surgery for the treatment of malignant spinal tumors. Nonetheless, many patients present with widespread tumor burden and minimal life expectancy, which excludes them from being surgical candidates. For these patients, palliative management is recommended. METHODS The authors reviewed prospective a...

Cryoablation is a safe and minimally invasive therapy option that provided rapid durable pain relief, as well an improved quality of life in participants with bone metastases.

INTRODUCTION: Pre-crisis planning is one of the important issues facing managers and planners, especially in the field of crisis management. In recent years, the world has faced an increasing number of natural and man-made disasters, such as earthquakes. Moreover, the growing effect of disasters on communities has highlighted the need for efficient and effective emergency logistics operations i...

OBJECTIVE To evaluate the efficacy and tolerability of MAP0004 compared with placebo for a single migraine in adult migraineurs: The FREEDOM-301 Study. BACKGROUND Acute treatment of migraine remains a clinical challenge despite the availability of triptans and other agents. Injectable dihydroergotamine, although effective, is considered invasive and inconvenient, and intranasal dihydroergotam...

Following the occurrence of unexpected events and natural disasters, a highly important relief operation is the transferring of relief commodities from the distribution centers (CDs) to shelters. In this paper, a three-level network consisting of depot of vehicles, distribution centers and shelters has been considered for routing and scheduling of relief vehicles through introducing a multi-obj...

BACKGROUND A recent article in the New Scientist argued that women were under-represented in clinical trials which, until now, had masked the finding that ibuprofen 400 mg was ineffective in women. METHODS Meta-analysis of randomised, double-blind placebo-controlled trials of ibuprofen 400 mg in acute pain, and use of individual patient information were planned to test the hypothesis that ibu...