Objective To identify the autoantigen defined by Anti-Neuronal Nuclear Antibody-type 3 (ANNA3)-IgG and describe clinical phenotype of seropositive patients. Background ANNA3 was described in 11 patients with multifocal neurological presentations cancer; its detection is based on characteristic immunofluorescence staining mouse tissue sections; ignorance antigen's molecular identity has preclude...

A large proportion of specific IgE occurred in immune complexes with anti-IgE autoantibodies in sera from nonhyposensitized allergic patients. These autoantibodies were misinterpreted as ‘specific IgG’ in different immunoassays such as dot immunoassays and the radioallergosorbent test (RAST), leading to overestimation of specific IgG. Purified immune complexes contained even more IgG than IgE a...

Nasal vaccine delivery is superior to oral delivery in inducing specific immunoglobulin A (IgA) and IgG antibody responses in the upper respiratory tract. Although an antibody response in the nasal passages is important in protecting against primary colonization with lung pathogens, antibodies in the lungs are usually required as well. We immunized 15 male volunteers twice nasally or orally wit...

Toxoplasma gondii is an intracellular protozoan parasite that causes toxoplasmosis and is of medical importance in pregnant women and immunosuppressed patients. In recent years, many methods have been developed for the detection of infection caused by this parasite; however, most of the developed methods are not adequately sensitive. The dense granular antigen (GRA) ...

Objective(s): New generation of allergy vaccines is capable of promoting the development of protective IgG and blocking the functionality of allergen-specific IgE. We incorporated universal and powerful T-cell epitopes from tetanus and diphtheria toxoids (TD epitope) into recombinant Che a 2, the well-known allergic profilin of Chenopodium album, to determine its immun...

objective: human cmv is the most causative agent of a very common viral infection contacted by most adults that have no noticeable or with only mild uncharacteristic symptoms. however when a pregnant women is infected with cmv as a primary infection, there is a risk for transmission of virus to the fetus as well as reactivation of virus in rare case. hcmv antibodies were already described in sp...

introduction : human cytomegalovirus (hcmv) is able to go into latency and is the most common cause of congenital infections in humans. its clinical manifestations range from asymptomatic forms to severe fetal damage, and in rare cases, fetal death due to abortion. this prospective cross-sectional study was designed to determine the seroprevalence of hcmv infection in pregnant women attending a...