The fracture behaviour of human cortical bone was analysed considering a miniaturized version of the Double Cantilever Beam (DCB) test. A specific data reduction scheme based on crack equivalent concept was used to obtain the resistance curves. The definition of the cohesive laws mimicking the fracture process was performed measuring the crack tip opening displacement by digital image correlati...

The Mayo and Flory mechanisms for the self-initiation of styrene polymerization were explored with B3LYP and BPW91 density functional calculations. The Diels-Alder dimer (AH) is the key intermediate, and the lowest energy pathway for AH formation is a stepwise mechanism via a gauche/sickle (*M2*Gs) or gauche/U-shaped (*M2*Gu) diradical. Ring closure of the 1,4-diradical to diphenylcyclobutane (...

Many patients fail to achieve a clinical benefit from ICI. Several scores have been developed improve ICI candidates selection but it is uncertain which one better predicts patients’ outcome. Here, we performed direct comparison of the most successful scores. This sub-analysis immunoblood prospective observational study that enrolled diagnosed with advanced solid tumors treated Main clinicopath...

Polychlorinated biphenyls (PCBs) are persistent contaminants that exist as complex mixtures in the environment. One problem faced by risk assessors is that the possible interactive effects of specific PCB congeners and related chemicals found in environmental and biological samples have not been systematically investigated. Some PCBs perturb Ca2+ homeostasis and cause protein kinase C (PKC) tra...

In this study, a carbon nanotube (CNT) buckypaper was interleaved in carbon-fiber-reinforced polymer (CFRP) composite to improve the interlaminar fracture toughness. Interleaving film of laminate-type poses risk deteriorating in-plane mechanical properties. Therefore, shear modulus and strength were measured prior estimating To evaluate effect on toughness CFRP, double cantilever beam (DCB) end...