The blood system is continuously replenished from a rare population of hematopoietic stem cells (HSCs) that balance self-renewal and differentiation. It is believed that HSCs emerge during embryogenesis from a population of hemogenic endothelial cells at sites like the aorta-gonad-mesonephros (AGM) region and placenta. Transplantation of HSCs is a widely utilized cell therapy for a range of gen...

More than 100 years ago, a young girl named Virginia O'Hanlon wrote a letter to Santa Claus. 1 A newspaper reporter, impressed by the girl's innocence, edi-torialized this quest to believe in a fantasy representing good in the world by penning the famous line, " Yes, Virginia, there is a Santa Claus. " This story came to mind a few weeks ago, when I was having breakfast with my daughter-in-law ...

Wherever there is cancer, there will be blood and blood vessels to support tumor growth. While the majority of anticancer drugs are designed to directly kill tumor cells, recent strategies are focusing on drugs that indirectly kill cancer cells by targeting the tumor microenvironment and tumor vasculature. This strategy gained a significant boost with the approval of the angiogenesis inhibitor ...

The choice of programming language, the approach by which students are taught and the software tools made available to students have been controversial issues in many ways. While there once was a consensus of some sort within the computer science education community, it is much more difficult to find common ground among those of us who teach introductory programming courses. The literature is e...