results results of the current study showed that the minimum inhibitory concentration value of cinnamaldehyde against m. tuberculosis was 200 µg/ml. moreover, rt-pcr data showed that a total of 25 genes were regulated by the cinnamaldehyde. of these, 12 genes were up-regulated, and 13 genes were down-regulated. conclusions cinnamaldehyde is a pattern to expand the new anti-tb drugs, because the...

Objective To analyze the discourse of nurse managers related to conditions that (dis)favor the control of tuberculosis in the elderly. Method This study is qualitative and was held in a city considered a priority in the control of tuberculosis in Paraiba. Data collection was carried out between February and May 2014, through semi-structured interviews with eleven nurse managers. French Discou...

The emergence of drug resistance in Mycobacterium tuberculosis is a major challenge in tuberculosis treatment and control. In addition, multidrug resistance (MDR) and, more broadly, extensive drug resistance (XDR) have hampered treatment with common antibiotics. Thus, an herbal medicine containing antimicrobial capability can be a good alternative to antituberculosis drugs. In this study, we re...

background tuberculosis (tb) is one of the earliest human diseases which still is considered a public health problem. both genetic and environmental factors may contribute the susceptibility to tuberculosis. objectives akt is a serine/threonine kinase that has an important role in several cellular processes such as cell cycle control, cell survival, and cellular immigration. the akt signaling p...

Tuberculosis is a global health problem with total of 1.4 million cases in 2015. Over the last decade, several studies have demonstrated potential role gut-lung axis treatment tuberculosis. The exact mechanism on tuberculosis still unknown, however modulation can be performed via probiotic administration. administered probiotics are capable inducing an immunomodulating effect which helps proces...

New therapies to control tuberculosis are urgently required because of the inability of the only available vaccine, BCG, to adequately protect against tuberculosis. Here we demonstrate that proteins of the Mycobacterium tuberculosis sulfate-assimilation pathway (SAP) represent major immunogenic targets of the bacillus, as defined by strong T-cell recognition by both mice and humans infected wit...

Tuberculosis (TB) is a disease found in about one third of the world population. There is some controversy on the role of exogenous reinfection; with some epidemiologists supporting it while others consider it irrelevant. However, even at a minimal level, the presence of exogenous reinfection is capable of generating hysteresis and supporting multiple endemic states when the basic reproduction ...

Tuberculosis is still one of the major global public health threats. Countries with low incidence must focus on exhausting the reservoir of future cases by preventing reactivation. Therefore, it is important to identify and effectively treat those individuals who have latent tuberculosis infection and who may develop active disease. The tuberculin skin test has been the standard for detection o...