Drug induced liver injury (DILI) leads to acute hepatitis in 10%, liver failure, and death in 30%. One of the major drugs causing DILI is Anti-tuberculous drugs and since tuberculosis is affecting 1/3rd of the total world population, their use is quite common. Use of Isoniazid (INH) is limited owing to hepatotoxicity following the stress produced by oxidative species. Silymarin has hepatoprotec...

Rifampin, an antibiotic widely used for the treatment of mycobacterial infections, produceshepatic, renal and bone marrow toxicity in human and animals. In this study, the protectiveeffects of vitamin C and n-acetylcysteine (NAC) on the toxicity of rifampin on HepG2 cellswere investigated.Human hepatoma cells (HepG2) were cultured in 96-well M of rifampin in the presence ofmicroplate and expose...

Rifampin, an antibiotic widely used for the treatment of mycobacterial infections, produceshepatic, renal and bone marrow toxicity in human and animals. In this study, the protectiveeffects of vitamin C and n-acetylcysteine (NAC) on the toxicity of rifampin on HepG2 cellswere investigated.Human hepatoma cells (HepG2) were cultured in 96-well M of rifampin in the presence ofmicroplate and expose...

Objective Paracrine disruption of growth factors in women with polycystic ovarian syndrome results in production of low quality oocyte, especially following ovulation induction. The aim of this study was to investigate the effects of metformin (MET), N-acetylcysteine (NAC) and their combination on the hormonal levels and expression profile of GDF-9, BMP-15 and c-Kit, as hallmarks of oocyte qual...

The nac gene product is a LysR regulatory protein required for nitrogen regulation of several operons from Klebsiella aerogenes and Escherichia coli. We used P22 challenge phage carrying the put control region from K. aerogenes to identify the nucleotide residues important for nitrogen assimilation control protein (NAC) binding in vivo. Mutations in an asymmetric 30-bp region prevented DNA bind...

The effect of high N-acetylcysteine (NAC) concentrations (10 and 50 mM) on antibiotic activity against 40 strains of respiratory pathogens was investigated. NAC compromised the activity of carbapenems (of mostly imipenem and, to lesser extents, meropenem and ertapenem) in a dose-dependent fashion. We demonstrated chemical instability of carbapenems in the presence of NAC. With other antibiotics...

introduction it has long been known that ionizing radiation can lead to detrimental effects in normal cells. in this light, radioprotective chemicals have been used to decrease morbidity or mortality caused by ionizing irradiation. this study aimed to evaluate the radio-protective effect of n-acetylcysteineagainst radiation-induced mortality in male mice. materials and methods 52 healthy male m...

n-acetyl cysteine (nac), as a nutritional supplement, is a greatly applied antioxidant in vivo and in vitro. nac is a precursor of l-cysteine that results in glutathione elevation biosynthesis. it acts directly as a scavenger of free radicals, especially oxygen radicals. nac is a powerful antioxidant. it is also recommended as a potential treatment option for different disorders resulted from g...