BACKGROUND Human γδ T cells reactive to the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP) contribute to acute inflammatory responses. We have previously shown that peritoneal dialysis (PD)-associated infections with HMB-PP producing bacteria are characterized by locally elevated γδ T-cell frequencies and poorer clinical outcome compared with HMB-PP negative infec...

Dietary restriction (DR) has been shown in a wide variety of model organisms, including Drosophila melanogaster, to increase lifespan and health span. It is unclear how much of this effect is due to a DR-induced increase in physical activity. β-hydroxyβ-methylbutyrate (HMB) supplementation has been shown in improve health span in Drosophila. The exact mechanism of this effect has not yet been e...

OBJECTIVE To investigate the efficacy and underlying mechanisms of β-hydroxy-β-methylbutyrate (HMB) on body composition, muscle mass and physical performance under catabolic versus normal training conditions. MATERIALS/METHODS Mice were divided into four groups (n=10/group): (1) ALT=ad libitum+trained (1 h/d for 3 d/wk); (2) ALTH=ALT+HMB (0.5 g/kg BW/d); (3) C=calorie restricted (-30%)+traine...

AIMS To evaluate immunohistochemistry and reverse transcriptase polymerase chain reaction (RT-PCR) for melanoma associated antigens (MAA) in detecting occult melanoma cells in lymph nodes which were missed on routine pathology. METHODS Occult melanoma cells were sought in 436 lymph nodes from 32 patients with cutaneous melanoma of the lower extremities by immunohistochemistry using the melano...

background: heavy menstrual bleeding of endometrial origin (hmb) is a major healthcare problem in premenopausal women and affects several aspects of women’s health and quality of life (qol). the aim of this study was to compare the efficacy of persian golnar (pg) and tranexamic acid (ta) on heavy menstrual bleeding of endometrial origin (hmb) and patients’ qol. methods : a double-blind randomiz...

Benign metastasizing leiomyoma (BML) refers to benign pulmonary neoplasm associated with a previous or coincident history of uterine leiomyomata. We report the case of a 56-year-old postmenopausal woman with a 4-year history of multiple benign leiomyomatous lesions in bilateral lungs and the uterus. The tumor cells from the lungs and uterus were focally immunoreactive for HMB-45 antibody and pr...

The aim of the present study was to investigate The effect of HMB-FA supplementation on the muscle damage markers after soccer matches. 24 male soccer players (age: 23±3 years, BMI: 22.8±2 kg/m2) were voluntarily selected as the statistical sample of this study and were divided into two Suppplement and Placebo groups (n=12). In this study, subjects participated in a weekly soccer microcycle wit...

the aim of the present study was to examine the effect of 8 weeks of resistance training and hmb supplementation on serum myostatin levels of non-athlete men. in this quasi-experimental study, 20 non-athlete men voluntarily participated in the study and were divided into experimental group (n=10, mean age 28.75±1.39 yr, height 179.83±4.30 cm, weight 81±5.27 kg and bf% 28.65±6.40) and control gr...