The transcription factors encoded by the E2A and early B cell factor (EBF) genes are required for the proper development of B lymphocytes. However, the absence of B lineage cells in E2A- and EBF-deficient mice has made it difficult to determine the function or relationship between these proteins. We report the identification of a novel model system in which the role of E2A and EBF in the regula...

The Galileo spacecraft passed close to Europa on 11 encounters, two of which (E12 and E26) came within 400 km the surface. In E12 data, there are perturbations in field plasma data consistent with effects a nearby plume (Jia et al., 2018). Huybrighs al. (2020, https://doi.org/10.1029/2020GL087806) report depletions proton flux one channel Energetic Particle Detector (EPD) as E26. They trace par...

Background In the Western world colorectal cancer is one of the leading causes of cancer-related mortality, and the second most common cancer in women and the third in men. Identification of prognostic markers capable of predicting patient response to chemotherapy is essential to determine more personalised and efficient treatment strategies in colorectal cancer, and may help identify novel the...

The transcription factors encoded by the E2A and early B cell factor ( EBF ) genes are required for the proper development of B lymphocytes. However, the absence of B lineage cells in E2A and EBF -deficient mice has made it difficult to determine the function or relationship between these proteins. We report the identification of a novel model system in which the role of E2A and EBF in the regu...

The time of origin, development, and morphology of neurons originating before the establishment of the cortical plate (preplate cells) were studied in the telencephalic vesicle of the rat from the embryonic day 10 (E10) to E15. The first postmitotic neurons settle superficial to the ventricular zone in the preplate at E12. We have observed mitotic figures in the preplate at E12 and E13, and reg...

Helicobacter pylori colonises the gastric mucosa of humans. The majority of organisms live in mucus. These organisms are an important reservoir for infection of the underlying epithelium. Cell culture models for H. pylori infection do not normally possess a mucus layer. The interaction of H. pylori with TFF1, a member of the trefoil factor family found in gastric mucin, is mediated by lipopolys...

A finite element analysis of intergranular normal stresses is performed in order to identify a possible statistical correlation between the and corresponding grain boundary type within polycrystalline aggregate. Elastic continuum grains cubic lattice symmetry are assumed analysis. Meaningful results obtained by analyzing first two moments on several types. Among five macroscopic parameters (5D)...