Background: MicroRNA-155 (miR-155) is upregulated during T cell activation, but the exact mechanisms by which it influences CD4+ T cell activation remain unclear. Objective: To examine whether the B and T lymphocyte attenuator (BTLA) is a target of miR-155 during naïve CD4+ T cell activation. Methods: Firefly luciferase reporter plasmids pEZX-MT01-wild-type-BTLA and pEZX-MT01-mutant-BTLA were ...

Objective(s): Various studies have been conducted to reduce the metastatic behavior of cancerous cells. In this regard, ectopic expression of anti-metastatic microRNAs by miR-mimic and miR-restoration-based therapies could bring new insights to the field. In the present study, the consequences of co-transfecting breast cancer cell lines with miR-193b and miR-31 were investigated via invasion an...

Ovarian cancer is often diagnosed in an advanced stage and associated with a high mortality rate. It assumed that early detection of ovarian could improve patient outcomes. Unfortunately, effective screening methods for diagnosis are still lacking. Extracellular RNAs circulating human biofluids can reliably be measured emerging as potential biomarkers cancer. In this systematic review, we prese...

objective(s):micrornas (mirnas) are small non-coding rna molecules that regulate gene expression. they have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (ckd). in the present study, we elucidated the role of micror...

epilepsy is the third most common chronic brain disorder which is characterized by an enduring predisposition to generate seizures. mesial temporal lobe epilepsy (mtle) is the most common type of refractory epilepsy. increasing evidence indicates that neuroinflammation plays a critical role in the pathogenesis of mtle. hundreds of micro-rnas have been found to be abnormally expressed in epilept...