Objectives: Liver is one of the most sensitive tissues to oxidant damage. Hence, the present study was conducted to compare the effects of Melissa officinalis (MO) extract and Atorvastatin on the activity of liver enzymes in rats. Materials and Methods: In this experimental study, 60 male Wistar rats were selected and allocated to six groups (n=10). The control group received a normal diet, sha...

background & aim: marshmallow (althaea officinalis) is one of the most popular medicinal plants used in traditional medicine with antibacterial and antioxidant properties. this study was conducted to evaluate the effects of marshmallow extract (althaea officinalis l.) administration on blood cells and biochemical parameters of carp liver. experimental: 150 carp (weighing 37.65 ± 4.40 g) wer...

Introduction: Silymarine extract is currently prescribed by some physicians for treatment of fatty liver disease. In the present study, the effect of administration of tablet containing silymarine extract on plasma homocysteine (Hcy), folate, vitamin B12 and liver enzymes activity in non-alcoholic steatohepatitis (NASH) was investigated. Materials and Methods: Seventy-four patients (40 female a...

background oral administration of pro- and prebiotics has recently been considered as an effective way for nonalcoholic fatty liver disease (nafld) recovery. objectives the current study aimed at evaluating the effect of supplementation with probiotics and/or prebiotics on liver function tests in patients with nafld. methods in this double blind, placebo-control clinical trial, 75 subjects with...

This research investigated the protective role of Leea macrophylla extract on CCl4-induced acute liver injury in rats. Different fractions of Leea macrophylla (Roxb.) crude extract were subjected to analysis for antioxidative effects. Rats were randomly divided into four groups as normal control, hepatic control, and reference control (silymarin) group and treatment group. Evaluations were made...

Total mitochondrial aspartate aminotransferase (EC 2.6.1.1), the sum of apo- and holo-mitochondrial aspartate aminotransferase activity in human serum, was measured by using a proteolytic method: inactivation of cytosolic aspartate aminotransferase with cytosolic aspartate aminotransferase-inactivating protease 401 from Streptomyces violaceochromogenes. Cytosolic aspartate aminotransferase is c...

A new heptapeptide GAGPHGG (OC1) was isolated from Carapax trionycis which was a traditional Chinese medicine (TCM) used for treatment of hepatic diseases. The structure of OC1 was characterized by MS, NMR techniques, together with amino acid sequence analysis. The hepatoprotective activity of OC1 was evaluated in vivo using the CCl4-induced acute liver injury model. Combining the pathological ...

BACKGROUND AND OBJECTIVE Serum alanine-aminotransferase (ALT) is being used as a surrogate test for preventing post-transfusion viral hepatitis. However, ALT elevation is influenced by many factors. We have studied ALT levels in 1,036 consecutive blood donors to determine their association with gender, obesity, and hepatitis virus infection markers. DESIGN AND METHODS In each donation asparta...

Introduction: Acetaminophen is a widely used analgesic and antipyretic drug. Although it is considered safe at therapeutic doses, at higher doses, might produces a centrilobular hepatic necrosis that can be fatal. In the present study, the effect of fennel seed on hepatotoxicity induced by acetaminophen was investigated. Correspondenc...

OBJECTIVES The increase of serum aspartate aminotransferase (AST) is generally found in hepatic, cardiac, muscular disease and hemolytic disorders of the red blood cell (RBC). The elevation of its activity is suspected in pathological conditions of these organs. However, instances without any of those conditions rarely exist. METHODS The experimental samples were obtained from a normal person...