OBJECTIVE To determine the efficacy of topical application of Tranexamic acid in controlling postoperative bleeding in open-heart surgery. STUDY DESIGN Double blind randomized control trial. PLACE AND DURATION OF STUDY Departments of Cardiac Surgery and Intensive Care of Armed Forces Institute of Cardiology and National Institute of Heart Diseases (AFIC-NIHD), Rawalpindi, Pakistan, from May...

BACKGROUND/AIMS To investigate the in vitro effect of a short time exposure to the anthracycline idarubicin on proliferation, protein synthesis, and motility of human Tenon's capsule fibroblasts in comparison with the antitumour antibiotic mitomycin C. METHODS After determination of effective concentrations of idarubicin, fibroblasts of the human Tenon's capsule were exposed to idarubicin or ...

This study optimized the fermentation conditions for producing glucanase from Burkholderia pyrrocinia B1213 using Jiuzao, a residue Baijiu distillation, as carbon source. The effects of Jiuzao particle size and concentration, type nitrogen source, urea initial pH, inoculum size, loading volume, shaking speed, temperature, surfactant incubation time on production by B. were investigated separate...

background: we evaluated the in vivo activity of bunium persicum (boiss) essential oil on infected mice with acute toxoplasmosis. methods: to evaluate prophylactic effects, male nmri mice received b. persicum essential oil at the concentrations of 0.05 and 0.1 ml/kg for 14 days . after 24 h mice were infected intraperitonealy with 1×10 4 tachyzoites of t. gondii, rh strain. in order to investig...

Blumea balsamifera is a very famous medicinal plant and functional tea in many countries of Asia. Ainaxiang tablets are preparation consisting flavonoids from B. balsamifera. Today, high performance liquid chromatography method was developed for simultaneous quantification 15 Tablets. The analysis performed on Kromasil C18 column (250 × 4.6 mm, 5 µm) with binary gradient mobile phase acetonitri...

The activity of five simulated antifungal regimens for eradication of catheter-related bloodstream Candida infection was evaluated with an in vitro pharmacodynamic model. Single-lumen central venous catheters were colonized with Candida species by sequentially incubating central venous catheters in plasma and then in growth medium (RPMI plus morpholinepropanesulfonic acid) containing a standard...

BACKGROUND AND AIMS Very few studies have compared continuous wound infiltration (CWI), continuous epidural infusion (CEI) and intravenous Patient Controlled Analgesia (PCA) with morphine in spine surgery. This study compared these modalities in patients undergoing microdissectomy. METHODS This prospective, randomized control trial was conducted on 75 patients of American Society of Anesthesi...

The objective of this study was to compare, by two experimental methods, the antimicrobial efficacy of different root canal filling pastes used in pediatric dentistry. The tested materials were: Guedes-Pinto paste (GPP), zinc oxide-eugenol paste (OZEP), calcium hydroxide paste (CHP), chloramphenicol + tetracycline + zinc oxide and eugenol paste (CTZP) and Vitapex. Fiven microbial strains (S. au...

OBJECTIVE This study was designed to determine the safety, pharmacokinetics and biologic effects of a human-mouse chimeric anti-CD20 monoclonal antibody (SCT400) in Chinese patients with CD20-positive B-cell non-Hodgkin's lymphoma (CD20(+) B-cell NHL). SCT400 has an identical amino acid sequence as rituximab, with the exception of one amino acid in the CH1 domain of the heavy chain, which is co...