Human serum albumin (HSA) is the most abundant plasma protein in the human body. HSA plays an important role in drug transport and metabolism. This protein has a high affinity to a very wide range of materials, including metals such as Cu2+ and Zn2+, fatty acids, amino acids and metabolites such as bilirubin and many drug compounds. In this study, we investigated the effects of co-amoxiclav, as...

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  Purpose: To compare early maladaptive schemas and coping styles in drug dependent and non-dependent prisoners of Zahedan city.   Materials and Methods: This was an ex post facto study. The population of the study consisted of all men prisoners of Zahedan prison in 2013. The participants were 240 prisoners among which 120 prisoners were selected by convenience sampling method and the rest by s...

background due to the chronic and recurrent nature of addiction, many people who quit drug addiction may slip back into the pattern of using drugs shortly after the detoxification period. emotion-regulation strategies and resilience play an important role in preventing the recurrences of substance abuse. objectives this study aimed to compare the effects of methadone-maintenance therapy (mmt) a...

Background Good drug regulation requires an effective system for monitoring and inspection of manufacturing and sales units. In India, despite widespread agreement on this principle, ongoing shortages of drug inspectors have been identified by national committees since 1975. The growth of India’s pharmaceutical industry and its large export market makes the problem more acute.   Methods The foc...

Drug Delivery In article number 2212206, Ying Zhao, Xiaolong Qi, Guangjun Nie, and co-workers propose a liver sinusoid capillarization hepatic stellate cells activation combined regulation strategy for fibrosis treatment. Liver fenestrae restoration enhances the transport efficiency of nanomedicine through wall, which represents promising approach

despite a quite short early history, computational drug design and discovery methods can now be efficient in reducing costs and speeding up drug developing procedure. melanocortin-4 receptor (mc4r) is a g protein-coupled receptor implicated in the regulation of body weight. despite its clinical reputation, there is a lack of in-depth knowledge about structure and behavior of mc4r in lipid bilay...

The anti-apoptotic protein Mcl-1 plays a major role in multiple myeloma (MM) cell survival as well as bortezomib- and microenvironmental forms of drug resistance in this disease. Consequently, there is a critical need for strategies capable of targeting Mcl-1-dependent drug resistance in MM. The present results indicate that a regimen combining Chk1 with MEK1/2 inhibitors effectively kills cell...

For analyzing prescription datasets, usually one wishes to identify drugs by classes, rather than by U.S. FDANational Drug Codes. We demonstrate how to utilize the NLM RxNorm online API to map NDCs to WHOAnatomical-Therapeutic-Chemical classes, and present statistics and caveats of mapping 71,309 NDCs found inMedicare Part D claims from 2006 to 2013 and 134,580 NDCs found in a c...