Vitamin B1 (thiamin) is required in the metabolism of carbohydrates, lipids, proteins, and energetic metabolism within Krebs cycle. It has also an essential role in acetylcholine synthesis and neurotransmission.1 Thiamin deficiency can lead to various manifestations such as Gayet-Wernicke syndrome, wet beriberi with congestive heart failure, or dry beriberi with peripheral neuropathy. We report...

Eight clinically proved cases of prolonged thiamine deficiency were evaluated by routine pathologic study. The msieroseopic features were evaluated by comparison with sections of myocardiuni obtained from nornmal individuals and individuals suffering from cardiac diseases of other varieties. No specific transitory or permanent alterations were demonstrable. It is concluded that beriberi heart d...

In his researches the author has made greater use of histological methods than any previous workers on the subject of deficiency diseases. From these studies and from clinical observation he has come to the conclusion that in addition to the special deficiency diseases like scurvy, beriberi, rickets, and pellagra there are many disorders of a gastro-intestinal nature that are due to defective d...

Eight clinically proved cases of prolonged thiamine deficiency were evaluated by routine pathologic study. The msieroseopic features were evaluated by comparison with sections of myocardiuni obtained from nornmal individuals and individuals suffering from cardiac diseases of other varieties. No specific transitory or permanent alterations were demonstrable. It is concluded that beriberi heart d...