Different energy infrastructures, such as electricity, natural gas and local district heating systems utilized for the energy supply are most often planned and operated independently of each other. This paper addresses the optimization of combined electricity and natural gas networks. The couplings between the two energy infrastructures are taken into account with the novel concept of energy hu...

The concept of multi-energy systems (MES) is widely applied in various areas energy supply. This approach makes it possible to analyze the distribution flows and their mutual influence both for local facilities power supply systems. At same time, currently, promising analysis, forecast, control behavior are those that employ innovative methods, example, different technologies mathematical model...

Creatine kinase (CK; EC 2.7.3.2) is related to several skin diseases such as psoriasis and dermatomyositis. CK is important in skin energy homeostasis because it catalyzes the reversible transfer of a phosphoryl group from MgATP to creatine. In this study, we predicted CK binding proteins via the use of bioinformatic tools such as protein-protein interaction (PPI) mappings and suggest the putat...

Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC). Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with tumor node metastasis (TNM) staging of BC patients. Functional enrichment analysis was conducted to functionally annotate the hub genes. Protei...

    Hub covering location problem, Network design,   Single machine scheduling, Genetic algorithm,   Shuffled frog leaping algorithm   Hub location problems (HLP) are synthetic optimization problems that appears in telecommunication and transportation networks where nodes send and receive commodities (i.e., data transmissions, passengers transportation, express packages, postal deliveries, etc....

The hub location problem is employed for many real applications, including delivery, airline and telecommunication systems and so on. This work investigates on hierarchical hub network in which a three-level network is developed. The central hubs are considered at the first level, at the second level, hubs are assumed which are allocated to central hubs and the remaining nodes are at the third ...

The integrated performance assessment of buildings can orient their design in the early stages. Despite wide availability physics simulation-based, data-driven, and hybrid techniques, it is often difficult to rely on a single, appropriate technique obtain reliable results. A set methods, each featuring advantages limitations, help refine an iterative comparative process until comprehensive pict...

In this paper, a stochastic programming approach is applied to the airline network revenue management problem. The airline network with the arc capacitated single hub location problem based on complete–star p-hub network is considered. We try to maximize the profit of the transportation company by choosing the best hub locations and network topology, applying revenue management techniques to al...

the hub location decision is a long term investment and any changes in it take considerable time and money. in real situations, some parameters are uncertain hence, deterministic models cannot be more efficient. the ability of two-stage stochastic programming is to make a long-term decision by considering effects of it in short term decisions simultaneously. in the two-stage stochastic programm...

this paper proposes a new mathematical model for designing and planning postal parcels carriage and postal networks. the objective of postal network designing is to determine the location, size and connection between the postal stations in a city, province or country. in this paper, a kind of multiple locations-allocations hub problem with limited capacity in collecting, distributing and broadc...