We study the problem of finding a genetic network from data obtained by multiple gene disruptions and overexpressions. We define a genetic network as a weighted graph, and analyze the computational complexity of the problem. We show that if there exists a weighted network which is consistent with given data, we can find it in polynomial time. Moreover, we also consider the optimization problem,...

BACKGROUND Intravenous immunoglobulin (IVIG) is the treatment of choice in Kawasaki disease (KD). IVIG is used to prevent cardiovascular complications related to KD. However, a proportion of KD patients have persistent fever after IVIG treatment and are defined as IVIG resistant. METHODS AND RESULTS To develop a risk scoring system based on genetic markers to predict IVIG responsiveness in KD...

BACKGROUND Approximately 20% of multiple sclerosis patients have a family history of multiple sclerosis. Studies of multiple sclerosis aggregation in families are inconclusive. OBJECTIVE To investigate the genetic burden based on currently discovered genetic variants for multiple sclerosis risk in patients from Dutch multiple sclerosis multiplex families versus sporadic multiple sclerosis cas...

Vendor managed inventory is a continuous replenishment program that is designed to provide major cost saving benefits for both vendors and retailers. Previous research on this area mainly included single objective optimization models where the objective is to minimize the total supply chain costs or to maximize the total supply chain benefits. This paper presents a bi-objective mathematical mod...

We study the possibility of using geometric operators in the selection of human resources. We develop three new methods that use the ordered weighted geometric (OWG) operator in different indexes used for the selection of human resources. The objective of these models is to manipulate the neutrality of the old methods so the decision maker is able to select human resources according to his part...

While the concept of regular equivalence is equally applicable to dichotomous as well as valued networks, the identification of regular blocks in regular blockmodels is somewhat problematic when dealing with valued networks. Applying the standard procedure for identifying ties in such blockmodels, a procedure perhaps most suited for dichotomous networks, does tend to generate block images and r...

This paper presents a novel, integer-linear programming (ILP) model for an identical parallel-machine scheduling problem with family setup times that minimizes the total weighted flow time (TWFT). Some researchers have addressed parallel-machine scheduling problems in the literature over the last three decades. However, the existing studies have been limited to the research of independent jobs,...

context the pnpla3 i148m variant has been recognized as a genetic determinant of liver fat content and a genetic risk factor of liver damage progression associated with steatohepatitis. the i148m variant is associated with many chronic liver diseases. however, its potential association with inflammatory and autoimmune liver diseases has not been established. evidence acquisition we systemically...