Seventy-four streptomycin (SM)-resistant M. tuberculosis clinical isolates were subjected to cross-resistance drug testing against two major aminoglycosides, kanamycin (KM) and amikacin (AMK). Among them, 15 clinical isolates (20.3%) were resistant to both KM and AMK. Fifteen (80%) of 19 KM-resistant isolates were AMK-resistant. Fifteen SM, KM, and AMK resistant isolates harbored rrs mutation, ...

BACKGROUND Mupirocin has been used for the treatment of skin infections and eradication of nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA). The increased use of this antibiotic has been accompanied by outbreaks of MRSA that are resistant to mupirocin. OBJECTIVE This study aims to determine the prevalence, genotype and antimicrobial susceptibility of mupirocin-resistant MR...

We determined that resistance to ciprofloxacin has emerged in enterococci over the last 5 years in our hospital, mainly in strains demonstrating the phenotype of high-level gentamicin resistance. All high-level-gentamicin-resistant isolates from 1985 and 1986 were susceptible, whereas 24% of isolates from 1989 and 1990 were resistant to ciprofloxacin. Plasmid and genomic DNA typing showed at le...

Tuberculosis (TB) remains one of the health problems in Nigeria and worldwide. Adenosine Deaminase acts proliferation differentiation lymphocyte, especially T lymphocyte. It also maturation monocytes transforming them to macrophage. is a significant indicator active cellular immunity. has been proposed be useful surrogate marker for TB because it can detected body fluids such as pleural, perica...

Pseudomonas aeruginosa is one of the most important pathogens that causes nosocomial infections and shows high level of antibiotic resistance. Integrons are one of the transposable elements in bacteria and their role in antibiotic resistance has been well demonstrated. The aim of this study was a molecular characterization of the integron genes and the determination of the resistance or sensiti...

Vancomycin is a glycopeptide antibiotic used for the treatment of Gram-positive bacterial infections. Traditionally, it has been used as a drug of last resort; however, clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) strains with decreased susceptibility to vancomycin (vancomycin intermediate-resistant S. aureus [VISA]) and more recently with high-level vancomycin resist...

the use of organophosphorus hydrolase (oph) enzyme to degrade chemical warfare agents is one of the most frequently used decontamination methods. oph is a ~36 kda homodimeric metalloprotein that is found in the membrane of flavobacterium sp. strain atcc 27551 and brevundimonas diminuta mg and is capable of hydrolyzing a wide range of oxon and thion , such as paraoxon and parathion. oph gene ( o...