نتایج جستجو برای: igfbp1
تعداد نتایج: 229 فیلتر نتایج به سال:
This study was to test the hypothesis that altered IGF2 system in the placental labyrinth zone (LZ) impairs feto-placental growth in response to maternal protein restriction. Rats were fed a 20% protein diet and an isocaloric 6 % protein diet (LP) from day 1 to days 14, 18, or 21 of pregnancy. The effects of diet, gender of placenta and fetus, and day of pregnancy on placental weight, fetal wei...
Trophoblast differentiation is a key event in human placental development. During extravillous trophoblast (EVT) differentiation, stem cells from the anchoring villi detach from their basement membrane and proliferate to form aggregates called trophoblast cell columns (TCCs). They subsequently invade the decidua and differentiate into interstitial and endovascular trophoblasts. The influence of...
Insulin receptor substrates, including Irs1 and Irs2, integrate insulin and IGF receptor signals with heterologous pathways to coordinate growth and metabolism. Since Irs2 is thought to be especially important in hepatic nutrient homeostasis, we deleted Irs2 [corrected] from hepatocytes of WT mice (called LKO) or genetically insulin-resistant Irs1-/- mice (called LKO::Irs1-/-). Viable LKO::Irs1...
Differentiation of human endometrial stromal cells (HESC) into decidual cells represents a highly coordinated process essential for embryo implantation. We show that decidualizing HESC down-regulate the histone methyltransferase enhancer of Zeste homolog 2 (EZH2), resulting in declining levels of trimethylation of histone 3 on lysine 27 (H3K27me3) at the proximal promoters of key decidual marke...
هدف از این پژوهش، شناسایی ژنها و کاوشگرهای هاب ناشی از ایجاد شبکههای بیزی در دادههای بیان ژن و کاوشگری در بافتهای مختلف گونۀ گاو با استفاده از دادههای ریزآرایۀ DNA بود. با استفاده از دادههای خام بیان ژن و کاوشگری در هر بافت، ژنها و کاوشگرهایی که عامل بیشترین میزان واریانس بیان ژن بودند، شناساییشده و سپس شبکۀ بیزی، برای آنها برازش داده شد. ژنها و کاوشگرهای هاب با استفاده از نسبت فراسن...
background: computational identification of phylogenetic motifs helps to understand the knowledge about known functional features that includes catalytic site, substrate binding epitopes, and protein-protein interfaces. furthermore, they are strongly conserved among orthologs, indicating their evolutionary importance. the study aimed to analyze five candidate genes involved in type ii diabetic ...
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