umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. it is extracted from dried roots of ferula szwitsiana collected from the mountains of golestan forest (golestan province, north of iran). induction of apoptosis in jurkat t-cll cells has been previously shown. in this study, effect of umbelliprenin on proapoptotic caspases (caspase-8 and -9) and antia...

Umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. It is extracted from dried roots of Ferula szwitsiana collected from the mountains of Golestan forest (Golestan Province, north of Iran). Induction of apoptosis in Jurkat T-CLL cells has been previously shown. In this study, effect of umbelliprenin on proapoptotic caspases (caspase-8 and -9) and antia...

Abstract Background Increasing evidence shows that endothelial apoptosis contributes to cigarette smoke (CS)-induced disease progression, such as chronic obstructive pulmonary (COPD). Our previous studies have validated Notch1 an anti-apoptotic signaling in CS-induced apoptosis. Resveratrol (RESV) is a naturally occurring polyphenol exhibits activity cells exposed many kinds of destructive stim...

Quercetin compounds have antioxidant, anti-inflammatory and anticancer pharmacological functions. Long-term exposure to acrylamide (AA) can cause liver injury endanger human health. However, whether quercetin attenuate AA-induced the specific mechanism are not clear. Here, we studied structure-activity relationship of in reducing hepatotoxicity vivo vitro. In studies found that quercetin-like p...

the radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. these changes are confirmed by results of some in-vivo s...

Cyclophilin D (CypD) is regulated during the innate immune response of insects. However, mechanism by which CypD activated under immunosuppression not understood. Microplitis bicoloratus bracovirus (MbBV), a symbiotic virus in parasitoid wasp, bicoloratus, suppresses immunity parasitized Spodoptera litura. Here, we demonstrate that MbBV promotes acetylation S. litura, resulting an immunosuppres...