Killing of Escherichia coli by hydrogen peroxide proceeds by two modes. Mode one killing appears to be due to DNA damage, has a maximum near 1 to 3 mM H2O2, and requires active metabolism during exposure. Mode two killing is due to uncharacterized damage, occurs in the absence of metabolism, and exhibits a classical multiple-order dose-response curve up to at least 50 mM H2O2 (J. A. Imlay and S...

Impulsive control strategies have been widely used in cancer treatment and linear impulsive has always considered previous studies. We propose a novel tumour-immune model with nonlinear killing rate as state-dependent feedback control, which can better reflect the saturation effects of tumour immune cell mortalities due to chemotherapy, its dynamic behaviors are investigated. The paper aims dis...

The in vitro interactions of two new antitubercular drugs, SQ109 and TMC207, with each other and with rifampin (RIF) were evaluated. The combination of SQ109 with TMC207 (i) improved an already excellent TMC207 MIC for M. tuberculosis H37Rv by 4- to 8-fold, (ii) improved the rate of killing of bacteria over the rate of killing by each single drug, and (iii) enhanced the drug postantibiotic effe...

We conducted genetic and functional analyses of isolates from a patient with group B streptococcal (GBS) necrotizing fasciitis and toxic shock syndrome. Tissue cultures simultaneously showed colonies with high hemolysis (HH) and low hemolysis (LH). Conversely, the HH and LH variants exhibited low capsule (LC) and high capsule (HC) expression, respectively. Molecular analysis demonstrated that t...

We present a classification of the hyperbolic Kac–Moody (HKM) superalgebras. The HKM superalgebras of rank r ≥ 3 are finite in number (213) and limited in rank (6). The Dynkin–Kac diagrams and the corresponding simple root systems are determined. We also discuss a class of singular sub(super)algebras obtained by a folding procedure. MSC number: 17B65, 17B67 LAPTH-1068/04 DSF-TH-28/04 math-ph/04...

Background/introduction The biologic dose response curves of thermal dose and absorbed radiation dose have not been compared to each other even though they have both been extensively investigated separately and combined. Although heat and radiation produce cell kill by different biological mechanisms (Thermal dose denatures proteins and the radiation dose causes DNA damage) a comparison of dose...