Objectives: The extract of Lippia citriodora and its main component, verbascoside, are known for their hypnotic effects in traditional medicine. In this study, the anxiolytic and hypnotic effects of L. citriodora leave extracts and verbascoside were evaluated in mice. Materials and Methods: Animals were divided into 11 groups of six mice each. Group I received normal saline, Group II received ...

Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively...

We investigated the effects of the second generation antipsychotics olanzapine, sertindole and clozapine on visual recognition memory using the novel object recognition (NOR) test in naive and MK-801-treated animals. The effects of drug treatment on locomotion and anxiety were also determined using the open field test. Male Balb-c mice were treated with olanzapine (0.2, 0.4 and 0.6 mg/kg; i.p.)...

Background: Ascorbic acid (AA) as a vitamin and neuromodulator is present in the most part of CNS such as nucleus accumbens shell (Acbsh), so the main purpose of this investigation was to evaluated the effect of AA and their Co-administration in Acbsh on anxiety and motor activity of rat by Open Field Test(OFT). Methods: Forty nine adult male Wistar rats (220-270 g) were used into 7 grou...

INTRODUCTION In the light of 3R (replace, reduce, refine) principles in animal experimentation and increased focus on delayed effects of treatment on central nervous system, the incorporation of behavioural tests into standard toxicology studies as a complement or substitution of a stand-alone safety pharmacology study appears very attractive, but poses some challenges. In the present study, we...

Objective: The study was undertaken to compare the effect of ondansetron, granisetron and alprazolam on anxiety in rats. Materials and Methods: Elevated plus maze and Open field test were used to compare the effect of drugs on anxiety in rats. Six groups of rats were treated with 2% gum acacia orally, alprazolam 0.08mg/kg body weight of the rat orally, ondansetron (0.01mg/kg, 1mg/kg intraperito...

Background & Aim:Cognitive impairment is one of the age-related mental problems and a typical indicator of neurodegeneration. Eragrostis tremula Hochst. ex Steud. is a commonly used medicinal plant in Nigeria for memory enhancement. This study, therefore, aimed at evaluating the memory-enhancing potential of aqueous ethanolic extract of E. tremula in ...

Animal models of stroke have been crucial in advancing our understanding of the pathophysiology of cerebral ischemia. Currently, the standards for determining neurological deficit in rodents are the Bederson and Garcia scales, manual assessments scoring animals based on parameters ranked on a narrow scale of severity. Automated open field analysis of a live-video tracking system that analyzes a...