AIM Molecular alterations at membrane, cytosol and nuclear level in cancer cells/tissue show variations in bioimpedance measure. In the present study, bioimpedance assessment and comparison was investigated between oral squamous cell carcinoma (OSCC) and normal tissue. Study further involves clinicopathological correlation of bioimpedance values in OSCC. MATERIALS AND METHODS The present stud...

head and neck squamous cell carcinoma, including oral squamous cell carcinoma (oscc) is the sixth most common cancer in the human population. despite significant efforts committed in treatment of oscc the overall survival rate of oscc has not improved significantly. activating mutations in the fibroblast growth factor receptor 3 (fgfr3) genes are responsible for some human cancers, including bl...

background: considering molecular target therapy concept in the treatment of oral squamous cell carcinoma (oscc), many attempts have been performed to introduce an effective molecular marker during recent years. several investigations have emphasized on the role of cd44 in various cancers and few studies have mentioned cd24 and cd74. the purpose of this study was to investigate the relationship...

Oral squamous cell carcinoma (OSCC) is one of the deadliest and most common types cancer. The incidence OSCC increasing annually, which requires early diagnosis to receive appropriate treatment. biopsy technique important techniques for analyzing samples, but it takes a long time get results. Manual still subject errors differences in doctors’ opinions, especially stages. Thus, automated can he...

Background and Aim: It has been suggested that oral lichen planus (OLP) can be a potential premalignant lesion. Reports are also available on the role of bcl-2 and p53 proteins in malignant transformation of OLP into oral squamous cell carcinoma (OSCC). Due to controversies in these reports, the present study aimed to compare the expression of p53 and bcl-2 markers in OLP and OSCC. Materials a...

CKS1B is a member of the highly conserved cyclin kinase subunit 1 (CKS1) protein family which interacts with cyclin-dependent kinases and plays a critical role in cell cycle progression. In oral squamous cell carcinoma (OSCC), as in other malignancies, CKS1B overexpression has been correlated with reduced survival. To our knowledge, no studies evaluating the genetic status of CKS1B gene in OSCC...

Worldwide oral squamous cell carcinoma (OSCC) represents about 5.5% of all malignancies, with f30,000 new cases each year in the United States. The integrin AvB6 and the enzyme cyclooxygenase-2 (COX-2) are implicated in OSCC progression and have been suggested as possible therapeutic targets. Each protein also is reported to identify dysplasias at high risk of malignant transformation, and curr...

PURPOSE This study aims to explore the presence of informative protein biomarkers in the human saliva proteome and to evaluate their potential for detection of oral squamous cell carcinoma (OSCC). EXPERIMENTAL DESIGN Whole saliva samples were collected from patients (n = 64) with OSCC and matched healthy subjects (n = 64). The proteins in pooled whole saliva samples of patients with OSCC (n =...