comnode classification within membrane residue curves (m-rcms) currently hinges on lyapunov’s theorem and therefore the computation of mathematically complex eigenvalues. this paper presents an alternative criterion for the classification of nodes within m-rcms based on the total membrane flux at node compositions. this paper demonstrates that for a system exhibiting simple permeation behaviour...

AIM To examine the biocompatibility of two commercial forms of mineral trioxide aggregate (MTA), by evaluating the morphology of an established cell line. METHODOLOGY The two cements were cast on glass cover slips and cured for 1 or 28 days. Saos-2 osteosarcoma cells were trypsinized and seeded at a density of 1 x 10(5) cells and were then placed in medium over the material-coated coverslips ...

Type 2 diabetes mellitus (T2DM), by definition is a heterogeneous, multifactorial, polygenic syndrome which results from insulin receptor dysfunction. It is an outcome of oxidative stress caused by interactions of reactive metabolites (RMs) interactions with lipids, proteins and other mechanisms of human body. Production of RMs mainly superoxide (O2(-)) has been found in a variety of predominat...

Nitric oxide (NO), essential for maintaining vascular tone, is produced from arginine by nitric oxide synthase. Plasma arginine levels are low in sickle cell anemia, and it is reported here that low plasma arginine is also found in our sickle transgenic mouse model that expresses human alpha, human beta(S), and human beta(S-Antilles) and is homozygous for the mouse beta(major) deletion (S+S-Ant...

Efficient electron transfer and conversion of L-arginine to L-citrulline and nitric oxide (NO•) by neuronal nitric oxide synthase (nNOS) requires calmodulin (CaM) binding. The present study focused on electron transfer ability of resting state CaM-free nNOS in presence of dinitrobenzene isomers (DNBs). NADPH oxidation (NADPH ox ) and acetylated cytochrome-c reduction (AcCyt-cred ) catalyzed by ...

In this research, polyvinylchloride based composite heterogeneous cation exchange membranes were prepared by the solution casting technique. Chitosan-co-iron nickel oxide nanoparticles were utilized as membrane surface modifier to improve the membranes electrochemical properties. The effect of additive nanoparticle concentration in the modifier solution on the properties of composite membranes ...

BACKGROUND AND PURPOSE Enhanced vascular permeability attributable to disruption of blood-brain barrier results in the development of cerebral edema after stroke. Using an in vitro model of the brain barrier composed of human brain microvascular endothelial cells and human astrocytes, this study explored whether small GTPase RhoA and its effector protein Rho kinase were involved in permeability...