Mycobacterial energy metabolism currently attracts strong attention as new target space for development of anti-tuberculosis drugs. The imidazopyridine Q203 targets the cytochrome bcc complex of the respiratory chain, a key component in energy metabolism. Q203 blocks growth of Mycobacterium tuberculosis at nanomolar concentrations, however, it fails to actually kill the bacteria, which may limi...

A short introduction to Integer Programming (IP). Problems leading to IP models. Some modelling tricks and reformulations. Geometry of linear IP. TUM matrices. Brief notes on polyhedral analysis. Separation theory. Chvatal cut hierarchy, Gomory cuts, Disjunctive cuts, RLT cut hierarchy. Iterative methods: Branch-and-Bound, Cutting Plane, Branch-and-Cut, Branch-and-Price. Lower bounds: Lagrangia...

The minimum size for splicing of a vertebrate intron is approximately 70 nucleotides. In Drosophila melanogaster, more than half of the introns are significantly below this minimum yet function well. Such short introns often lack the pyrimidine tract located between the branch point and 3' splice site common to metazoan introns. To investigate if small introns contain special sequences that fac...

We present results of a binary population synthesis study on the orbital period distribution of wide binary millisecond pulsars forming through four evolutionary channels. In three of the channels, the progenitor of the millisecond pulsar undergoes a common envelope phase prior to the supernova explosion which gives birth to the neutron star. In the fourth channel, the primary avoids the common...

Supply chain management (SCM) is a subject that has found so much attention among different commercial and industrial organizations due to competing environment of products. Therefore, integration of constituent element of this chain is a great deal. This paper proposes a multi objective production-allocation and distribution planning problem (PADPP) in a multi echelon supply chain network. We ...

Abstract: The motive of the study is to establish a seepage flow model of pinnate horizontal well in infinite reservoir according to the characteristics of 3D distribution of CBM pinnate horizontal well. Taking flow pressure drop along the main and branch boreholes into consideration, the fluid flow formulas of CBM pinnate horizontal well are proposed. The corresponding calculation program has ...

This paper provides a framework in order to incorporate reliability issue as a sign of disruption in distribution systems and partial covering theory as a response to limitation in coverage radios and economical preferences, simultaneously into the traditional literatures of capacitated facility location problems. As a result we develop a bi-objective model based on the discrete scenarios for e...

In any supply chain, distribution planning of products is of great importance to managers. With effective and flexible distribution planning, mangers can increase the efficiency of time, place, and delivery utility of whole supply chain. In this paper, inventory routing problem (IRP) is applied to distribution planning of perishable products in a supply chain. The studied supply chain is compos...

This presentation is intended to be a short course on inference and filtering in hidden Markov models (HMMs) and state space models. These models comprise a hidden (unobserved) Markov chain (either with discrete or continuous state space) that governs the distribution of an observed stochastic process. An example of a HMM is a regime-switching model for stock returns in which the stock return d...