The purpose of the study was to examine potential differences between male and female alpine ski naive young people in attitudes towards alpine skiing before and after the completion of structured alpine ski school program. We included 136 ski beginners (41 women and 95 men) who anonymously filled out a previously validated 26-item Lickert scale-type questionnaire related to their attitudes tow...

In an attempt to develop a new anticancer platinum complex with greater or equivalent antitumor activity but reduced side effects compared with cisplatin (CDDP), a series of new platinum complexes having a glycolate leaving ligand was synthesized. Among them, five complexes were selected for further development on the basis of adequate water solubility, low nephrotoxicity and high antitumor act...

Transcription factor Glioblastoma-3 (Gli3) is cleaved in the anterior region of the limb bud to generate its repressor form. In contrast, Sonic hedgehog (Shh) signaling from the posterior zone of polarizing activity blocks Gli3 processing and then induces the expression of Gli3 target genes, including Gli1. Here we report that the Ski corepressor binds to Gli3 and recruits the histone deacetyla...

No long-term injury surveillance programs exist for competitive skiing or snowboarding. The objective of this study was, therefore, to compare different methods to record injuries among World Cup athletes in alpine, freestyle, and cross-country skiing, snowboarding, ski jumping and Nordic combined. Information regarding injuries sustained during the 2006-2007 winter season was recorded through ...

A Green Winter: The Case of Proposed Jiminy Peak Mountain Resort Wind Turbine John MacArthur; Thomas Barton WHEN CONSUMERS REEL FROM THE STICKER SHOCK OF HIGH ENERGY COSTS, smart business managers are looking for creative and profitable ways to insulate themselves from the vagaries of the energy marketplace. This teaching case is about a successful medium-sized ski resort in the Berkshire Mount...

The Ski oncoprotein dramatically affects cell growth, differentiation, and/or survival. Recently, Ski was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. These divergent roles of Ski are probably dependent on Ski's capacity to bind multiple partners with disparate functions. In particular, Ski alter...

The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins. The crystal structure of the Smad4 binding domain of human c-Ski in complex with the MH2 domain of Smad4 reveals specific recognition of the Smad4 L3 loop region by a highly conserved interaction loop (I loop) from Ski. The Ski binding surface on Smad4 significantly overlaps with tha...

This article investigates the impact of introduction a greatly reduced seasonal ski pass for overnight stays in winter destinations. The analysis covers 59 sports destinations Switzerland seasons 2012/2013 to 2017/2018, which 11 introduced "Magic Pass." Winter without constituted control group. Panel difference-in-differences estimates show that Magic Pass 2017/2018 led an increase domestic sea...

O n 2 July 2003, the International Olympic Committee (IOC) awarded Canada with the rights to host the 2010 Winter Games. The XXI Olympic and X Paralympic Winter Games took place from 12 to 28 February and from 12 to 21 March 2010, respectively, in the Vancouver, British Columbia, and Whistler, British Columbia, areas. The 2010 Winter Games showcased the highest-level competition at five indoor ...