abstract  introduction: diabetes mellitus is the most common metabolic and endocrine disease. depressed heart rate variability (hrv) is an early warning sign of diabetic neuropathy. in numerous studies, spironolactone improved hrv and decreased mortality in congestive heart failure (chf). this study was performed to assess the effect of spironolactone on hrv in diabetic patients. methods: this ...

Many Six Sigma practitioners use “Student’s” independent two-sample t-test when investigating differences in means. This type of test is based upon drawing random samples from two independent normal (Gaussian) distributions. Often, however, the assumption of normality and/or random sampling is violated. This article discusses when and why the two-sample t-test may be considered robust to these ...

Five inferential methods employed in single-case studies to compare a case to controls are examined; all of these make use of a t-distribution. It is shown that three of these ostensibly different methods are in fact strictly equivalent and are not fit for purpose; they are associated with grossly inflated Type I errors (these exceed even the error rate obtained when a case's score is converted...

In clinical research, comparisons of the results from experimental and control groups are often encountered. The two-sample t-test (also called independent samples t-test) and the paired t-test are probably the most widely used tests in statistics for the comparison of mean values between two samples. However, confusion exists with regard to the use of the two test methods, resulting in their i...