Inflammatory bowel diseases are associated with increased risk for thrombotic complications, In patients with ulcerative colitis (UC) cerebral sinus venous thrombosis (CSVT) is an extremely rare complication. We report a patient with active UC and CSVT. The patient was heterozygous for Factor V Leiden and G20210A prothrombin gene mutations without other identifiable precipitating factors. This ...

background: recurrent pregnancy loss (rpl) defined by two or more failed pregnancies before 20 weeks of gestation. several factors play a role in rpl including thrombophilic conditions which can be influenced by gene polymorphisms. plasminogen activator inhibitor-1 (pai-1) and angiotensin converting enzyme (ace) genes are closely related to fibrinolytic process, embryonic development and pregna...

Association between thrombophilia and pre-eclampsia is a controversial issue as Several case-control studies found at least 1 thrombophilic defect in 40% to 72% of women with pre-eclampsia compared with 8% to 20% of control women with normal pregnancies(4,5,6). But several other studies found no difference in the prevalence of thrombophilia between women with pre-eclampsia and those with normal...

We describe a patient with inherited plasminogen deficiency who developed extensive cerebral venous thrombosis. Several other conditions that might have contributed to a hypercoagulable state, including mild thrombocytosis, thyrotoxicosis, and a chronic inflammatory lung disorder, were present. We also discuss the evidence linking plasminogen deficiency with a thrombophilic state. The diagnosis...

Recurrent pregnancy loss (RPL) is usually defined as the loss of three or more consecutive pregnancies before 20 weeks of gestation. Within this definition is a large and heterogeneous group of patients with many different causes of miscarriage. RPL is a common clinical problem that occurs in approximately 1 % of reproductive-aged women. However, this frequency increases up to 5% when clinician...