objective: self-harm was classified to show forms like non-suicidal self injury and indirect risky behaviors and drug abuse. the aims of this study were to compare suicidal tendencies indexes and difficulty in emotion regulation skills in mixed groups of adolescents with direct and indirect forms of self-harm. methods: in a casual-comparative design from population of delinquent adolescents det...

PURPOSE This study investigated the trade-off in tumor coverage and organ-at-risk sparing when applying dose escalation for concurrent chemoradiation therapy (CRT) of mid-esophageal cancer, using radiobiological modeling to estimate local control and normal tissue toxicity. METHODS AND MATERIALS Twenty-one patients with mid-esophageal cancer were selected from the SCOPE1 database (Internation...

PURPOSE To develop a model for reoxygenation dynamic and its relationship to local control after radiotherapy (RT), based on repeated dynamic [18F]-fluoromisonidazole (FMISO) positron emission tomography (PET) examinations in head-and-neck cancer patients. METHODS AND MATERIALS Ten head-and-neck cancer patients were examined with dynamic FMISO PET before RT with 70 Gy and after approximately ...

Background: Bacterial DNA has immunostimulatory effects on different types of immune cells such as dendritic cells (DCs). Application of DCs as a cellular adjuvant represents a promising approach in the immunotherapy of infectious disease and cancers. Objectives: To investigate the effect of tumor antigen pulsed DCs in the presence of CpG-1826 in treatment of a murine model of cancer. Methods: ...

OBJECTIVE To compare the radiobiological response between simultaneously dose-escalated and non-escalated intensity-modulated radiation therapy (DE-IMRT and NE-IMRT) for patients with upper thoracic esophageal cancer (UTEC) using radiobiological evaluation. METHODS Computed tomography simulation data sets for 25 patients pathologically diagnosed with primary UTEC were used in this study. DE-I...

In order to achieve the maximum flexibility in adaptation to ever changing customer’s expectations in customer relationship management, appropriate measures of customer behavior should be continually monitored. To this end, control charts adjusted for buyer’s/visitor’s prior intention to repurchase or visit again are suitable means taking into account the heterogeneity across customers. In the ...