OBJECTIVE To study the effect of the short-acting insulin secretagogue nateglinide in patients with maturity-onset diabetes of the young type 3 (MODY3), which is characterized by a defective insulin response to glucose and hypersensitivity to sulfonylureas. RESEARCH DESIGN AND METHODS We compared the acute effect of nateglinide, glibenclamide, and placebo on prandial plasma glucose and serum ...

BACKGROUND The aim of the present study was to investigate the effect of ginger and glibenclamide on oxidative stress markers. Oxidative stress is caused by an unbalance between a relative overload of oxidants and depletion of antioxidants, as implicated in the pathogenesis of several chronic diseases, including atherosclerosis and diabetes mellitus. Regarding the role of oxidative stress in th...

The antidiabetic agent glyburide (glibenclamide) is frequently used for the treatment of type II diabetes and is increasingly being used for the treatment of gestational diabetes. Evidence suggests that breast cancer resistance protein/ATP-binding cassette, subfamily G, member 2 (ABCG2) expressed in the placenta protects the fetus against the accumulation of glyburide. A number of studies have ...

Background: Diabetes mellitus (DM) is a chronic disease inducing short-term and long-term complications including sexual dysfunction (SD) which can consequently reduce patients’ quality of life. Given the limited literature on frequency of SD in men experiencing diabetes in northern Iran, the present study was conducted in the city of Sari in Mazandaran Province, with the aim of investigating S...

in an attempt to determine the clinical value of frnctosamine assay for monitoring type ii diabetic patients, correlation of frnctosamine with glycosylated hemoglobin was studied. 100 patients with type ii diabetes mcllitus were compared with 100 normal subjects. fasting blood glucose, glycosylated hemoglobin, albumin and frnctosamine were measured in alt subjects. in the diabetic patients, a s...

  Background : Magnesium is the second most abundant intracellular cation. It plays an important role in insulin homeostasis and glucose metabolism through multiple enzymatic reactions. With increasing data on magnesium deficiency in diabetic patients and epidemiological studies demonstrating magnesium deficiency as a risk factor for diabetes, it is logical to search for its possible beneficial...

Aloe buettneri was evaluated to confirm its hypoglycemic activity. The presence of quinone which seem to leave the hypoglycemic activity. Lyophilisate of A. buettneri leaf (LA) causes hypoglycemia only 2 h after its administration and is linked to the presence of quinone. Glycemia reduction with LA was significantly higher than that of Glibenclamide, the control. Glibenclamide and LA negatively...

lowering the glucose level in diabetic patients reduces the risk of many consequences which are usually reported in these patients. non-insulin dependent (type ii) diabetes which cannot be controlled with sulfonylureas alone can be controlled with a combination of sulfonylurea and insulin. in an open randomized trial 58 patients were divided into three groups. the first group received only insu...

aim : to determine the prevalence of gastrointestinal symptoms and signs among persons with diabetes mellitus in a specialist hospital. background : gastrointestinal symptoms and signs are common among patients with diabetes mellitus. morbidity from patients and methods : in this descriptive, cross-sectional study, subjects from the general population with diabetes (n=200) were recruited for th...