This paper examines possible shortfalls in the design of Knowledge Management Systems (KMS) and proposes a way to design more effective KMS using meta-knowledge. We develop a theoretical framework for identifying the best design features necessary to support effective KM in organizations. We then apply this framework to identify possible weaknesses of 40 KMS in four different categories of tool...

Multiple myeloma (MM) is a malignant disease caused by an abnormal proliferation of plasma cells, of which the prognostic factors include chromosomal abnormality, β-2 microglobulin, and albumin. Recently, the term chromothripsis has emerged, which is the massive but highly localized chromosomal rearrangement in response to a one-step catastrophic event. Many studies have shown an association of...

Aghoutane Elmouhtadi*, MD; Fezzazi Redouane, MD Department of Orthopedic Pediatric Surgery, Medical University Hospital Mohammed VI, Faculty of Medicine and Pharmacy, Marrakech, Morocco Received: Oct 19, 2011; Accepted: Apr 08, 2012; First Online Available: Jan 17, 2013 Kabuki make-up syndrome (KMS) is a rare multiple congenital anomalies/mental retardation syndrome of unknown cause, first desc...

Knowledge management system (KMS) is crucial for organization knowledge management. In order to help the evaluation and selection of KMS from the user’s perspective, a new multiple criteria decision making (MCDM) method combining quality function deployment (QFD) with technique for order preference by similarity to an ideal solution (TOPSIS) in intuitionistic fuzzy environment is proposed. In t...

Knowledge Management (KM) and Knowledge Management Systems (KMS) have been positioned as strategies and tools that enable organizations to create and transfer knowledge in order to sustain competitive advantage. While Knowledge Management as a strategy was able to gain legitimacy, KMS struggled to prove a causal relationship to knowledge creation and knowledge transfer. KMS contribution to the ...

We reported previously the enhanced phosphoinositide metabolism and constitutive activation of phosphoinositide-specific phospholipase C (PLC) in two colorectal carcinoma cell lines, KMS-4 and KMS-8, derived from familial adenomatous polyposis patients. To study the physiological role of enhanced PLC activity in these cells, we analyzed the effect of PLC inhibitor (PCI) peptides on their growth...