Right This research was originally published in Journal of Biological Chemistry. Nobuhiro Suzuki; YoungMin Kim; Zui Fujimoto; Mitsuru Momma; Masayuki Okuyama; Haruhide Mori; Kazumi Funane; Atsuo Kimura. Structural Elucidation of Dextran Degradation Mechanism by Streptococcus mutans Dextranase Belonging to Glycoside Hydrolase Family 66. Journal of Biological Chemistry. 2012; 287:19916-19926. © t...

Current literature suggests that grassland degradation occurs in areas with poor soil conditions or noticeable environmental changes and is often a result of overgrazing or human disturbances. However, these views are questioned in our analyses. Based on the analysis of satellite vegetation maps from 1984, 1998, and 2004 for the Xilin River Basin, Inner Mongolia, China, and binary logistic regr...

Gene therapy as a modern therapeutic approach has not yet advanced to a globally-approved therapeutic approach. Lack of adequate reliable gene delivery system seems to be one of the major reasons from the pharmaceutical biotechnology point of view. Main obstacles delaying successful application of human gene therapy are presented in this review. The unique advantages of non-biological gene carr...

Curcumin is a bioactive compound from turmeric which has different biological properties and health benefits such as antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. However, the low solubility, poor bioavailability, and rapid degradation under neutral or alkaline pH conditions or when exposed to light, limit the food applications of curcumin. These problems can be solv...

To the Editors: The recent interesting article by Dhillon et al. (1) evaluated the clinical biological effects of curcumin against advanced pancreatic cancer. One important puzzle arising from this study involves how the biological activities are done with the precondition of the low nanogram levels of circulating curcumin (only 22-41 ng/mL were detectable in plasma even at oral dose of 8 g/d; ...

Composting is a natural process that occurs as result of microbial succession and marks the degradation stabilization organic matter in waste. The use additives during composting believed to be highly efficient, it increases production various enzymes, resulting faster rate waste degradation. converts into humus-like substance can enhance physical, chemical, biological properties soil. In this ...

The androgen receptor (AR) controls several biological functions including prostate cell growth and apoptosis. However, the mechanism by which AR maintains its stability to function properly remains largely unknown. Here we show that Akt and Mdm2 form a complex with AR and promote phosphorylation-dependent AR ubiquitylation, resulting in AR degradation by the proteasome. The effect of Akt on AR...

Inertness and the indiscriminate use of synthetic polymers leading to increased land and water pollution are of great concern. Plastic is the most useful synthetic polymer, employed in wide range of applications viz. the packaging industries, agriculture, household practices, etc. Unpredicted use of synthetic polymers is leading towards the accumulation of increased solid waste in the natural e...

Infertility as a vital process in human reproduction involves many couples worldwide. Although many genetic causes of infertility are known, the genetic basis of infertility in men is largely unknown. Therefore, the identification of genetic biomarkers in this field is important and genetic polymorphisms in key genes of the spermatogenesis pathway can be valuable biomarkers in this field. Gene'...

An increasing diversity of emerging contaminants are entering urban surface water and wastewater, posing unknown risks for the environment. One of the main contemporary challenges in ensuring water quality is to design efficient strategies for minimizing such risks. As a first step in such strategies, it is important to establish the fate and degradation behavior of contaminants prior to any en...