The deep convective boundary layer (CBL) in the Taklimakan Desert plays an important role climate system East Asia. Based on observation experiment and large-eddy simulation, turbulent mechanisms for its formation were revealed this study. This explained why daily maximum CBL depth was independent of surface heating. In late-morning, there a weak temperature inversion near-neutral residual (RL)...

Vitamin B12, or cobalamin (Cbl), is an essential nutrient. Acquisition, transport, and cellular internalization of Cbl are dependent on specific binding proteins and associated receptors. The circulating transport protein transcobalamin (TC) promotes cellular uptake via binding to specific receptors such as CD320, a receptor upregulated in several cancer cell lines. In this study, we report the...

Cbl (cobalamin) utilization as an enzyme cofactor is dependent on its efficient transit through lysosomes to the cytosol and mitochondria. We have previously proposed that pathophysiological perturbations in lysosomal function may inhibit intracellular Cbl transport with consequences for down-stream metabolic pathways. In the current study, we used both HT1080 fibroblasts and SH-SY5Y neurons to...

Members of the Cbl protein family (Cbl, Cbl-b, and Cbl-c) are E3 ubiquitin ligases that have emerged as critical negative regulators of protein tyrosine kinase (PTK) signaling. This function reflects their ability to directly interact with activated PTKs and to target them as well as their associated signaling components for ubiquitination. Given the critical roles of PTK signaling in driving o...

This paper describes the application of the Challenge Based Learning (CBL) methodology to cybersecurity education. The overall goal is to improve student learning via a multidisciplinary approach which encourages students to collaborate with their peers, ask questions, develop a deeper understanding of the subject and take actions in solving real-world challenges. In this study, students establ...

This paper details the design and use of a learning resource for independent learning in chemistry. The course presents chemistry in the context of sport and draws upon a number of models of teaching and learning, including the Perry scheme of intellectual development, multiple intelligences (MI) theory, problem/context-based learning (P/CBL), mind mapping, case studies and web-based independen...

This paper presents design and implementation of TDC based on time stamping using current balanced logic (CBL) buffer in 0.35 μm CMOS technology. The CBL logic buffer provides smaller delay compared to widely used current starved inverter, allowing better resolution in a given technology node. The CBL buffer based tapped delay line (TDL) provides accurate reference timing signals for time stamp...

Since the presence of analogues of vitamin B12 (B12, cobalamin, Cbl) has been postulated as the basis for the high values obtained by some radioisotope dilution assays (RIDA) of serum Cbl we examined serum for analogues. None could be demonstrated in the extracts of serum prepared for RIDA as sought by both direct and indirect techniques. The natural forms of serum Cbl were converted to cyanoco...