In the long-term management of ulcerative colitis patients, repeat dosing maybe required. Since 5-ASA is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug delivery with fewer side effects and a higher efficacy. The aim of this study was to prepare and evaluate a double coated multiparticulate system for 5-ASA deliver...

background : cesarean section rates are rising in many countries and the result of it is increase in maternal and prenatal morbidity and mortality rates. we assessed the content and concurrent validity of constructs of behavioral intention model (bim) scales to evaluate safer choices by pregnant women to select their method of delivery. methods: this was a quasi-experimental study that carried ...

background: the increase in the prevalence of cesarean section (c-section) in recent decades has become a public health problem worldwide. studies of cesarean section in order to identify the causes and form policies and interventions to reduce the incidence of this health problem are necessary. this study was conducted with the aim to investigate the causes of c-sections performed at niknafs a...

the main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of methocel® k15, ethocel® standard 7fp premium, eudragit ® rs100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. risperidone floating tablets were formulated by wet granulati...

Conventional transdermal drug delivery systems (TDDS) have been designed for drug delivery through the skin. These systems use the permeability property of stratum corneum, the outermost surface layer of the skin. Applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...

Background: Intravenous drug delivery is an advantageous choice for rapid administration, immediate drug effect, and avoidance of first-pass metabolism in oral drug delivery. In this study, the synthesis, formulation, and characterization of atorvastatin-loaded polyurethane (PU) nanoparticles were investigated for intravenous route of administration. Method: First, PU was synthesized and charac...

introduction: to present our experience about the safety of conservative management in asymptomatic and non-complicated hepatic hydatid cyst in pregnancy.   methods: seven pregnant patients with hepatic hydatid cysts as an incidental finding in routine obstetrical ultrasonography were referred to our center during 2001 to 2008. three patients were visited in the second and the rest in the third...

the purpose of the present study was to develop glipizide controlled release nanoparticles using alginate and chitosan thorough ionotropic controlled gelation method. glipizide is a frequently prescribed second generation sulfonylurea which lowers the blood glucose in type-two diabetics. quick absorption of the drug from the gastrointestinal tract along with short half- life of elimination make...