Many weighted scale-free networks are known to have a power-law correlation between strength and degree of nodes, which, however, has not been well explained. We investigate the dynamic behavior of resource-traffic flow on scale-free networks. The dynamical system will evolve into a kinetic equilibrium state, where the strength, defined by the amount of resource or traffic load, is correlated w...

Free-energy-based reinforcement learning (FERL) can handle Markov decision processes (MDPs) with high-dimensional state spaces by approximating the state-action value function with the negative equilibrium free energy of a restricted Boltzmann machine (RBM). In this study, we extend the FERL framework to handle partially observable MDPs (POMDPs) by incorporating a recurrent neural network that ...

The evolution of RNA conformation with Mg(2+) concentration ([Mg(2+)]) is typically determined from equilibrium titration measurements or nonequilibrium single [Mg(2+)]-jump measurements. We study the folding of single RNA molecules in response to a series of periodic [Mg(2+)] jumps. The 260-residue catalytic domain of RNase P RNA from Bacillus stearothermophilus is immobilized in a microfluidi...

The complex between the tumor suppressor p53 and its down-regulator Mdm2 has been studied by dynamic force spectroscopy and the unbinding data have been analyzed in the framework of the Jarzynski theoretical approach. Accordingly, the unbinding equilibrium free energy has been determined from the work done along several non-equilibrium paths from the bound to the unbound state in the single mol...

It appears that equilibrium unfolding transitions of many small proteins can be described as two-state transitions, because the probes commonly used to measure such transitions cannot detect the underlying heterogeneity inherent in protein folding and unfolding reactions. Time-resolved fluorescence or Forster resonance energy transfer (TRFRET) measurements have the potential to uncover such het...

The application of the latest digital technologies changes the ways of thinking of entrepreneurial behaviour and motivation of decision-making, principles of organization of their functioning, so the purpose of work is to form a model of achieving a balanced balance between economic efficiency and environmental and social responsibility of the digitized enterprise, determining the scientific ba...

Activation of the innate immune system by free heme has been proposed as one of the principal consequences of cell-free hemoglobin (Hb) exposure. Nonetheless, in the absence of infection, heme exposures within a hematoma, during hemolysis, or upon systemic administration of Hb (eg, as a Hb-based oxygen carrier) are typically not accompanied by uncontrolled inflammation, challenging the assumpti...

One reason that free energy difference calculations are notoriously difficult in molecular systems is due to insufficient conformational overlap, or similarity, between the two states or systems of interest. The degree of overlap is irrelevant, however, if the absolute free energy of each state can be computed. We present a method for calculating the absolute free energy that employs a simple c...