In current scenario several commercial and social organizations are using computer networks for their business and management purposes. In order to meet the business requirements networks are also grow. The growth of network also promotes the handling capability of large networks because it counter raises the possibilities of various faults in the network. A fault in network degrades its perfor...

The aim of the current study was to identify hub pathways of rheumatoid arthritis (RA) using a novel method based on differential pathway network (DPN) analysis. The present study proposed a DPN where protein‑protein interaction (PPI) network was integrated with pathway‑pathway interactions. Pathway data was obtained from background PPI network and the Reactome pathway database. Subsequently, p...

The objective of this study was to identify hub genes and pathways associated with hepatocellular carcinoma (HCC) by centrality analysis of a co-expression network. A co-expression network based on differentially expressed (DE) genes of HCC was constructed using the Differentially Co-expressed Genes and Links (DCGL) package. Centrality analyses, for centrality of degree, clustering coefficient,...

Air freight network is one of the important means to improve the competitiveness of express enterprises. This paper establishes the model from two aspects, hub location decisions and hub number decisions, with the goal to achieve the lowest air freight network cost, based on the “hub-spoke” theory. Then, computes the cost of different number of hubs, and uses super-efficiency DEA model to decid...

In this paper, a hub covering location problem is considered. Hubs, which are the most congested part of a network, are modeled as M/M/C queuing system and located in placeswhere the entrance flows are more than a predetermined value.A fuzzy constraint is considered in order to limit the transportation time between all origin-destination pairs in the network.On modeling, a nonlinear mathematica...

This paper studies a closed queueing network containing a hub (a state dependent queueing system with service depending on the number of units residing here) and k satellite stations, which are GI/M/1 queueing systems. The number of units in the system, N , is assumed to be large. After service completion in the hub, a unit visits a satellite station j, 1 ≤ j ≤ k, with probability pj , and, aft...

A variety of different network technologies and topologies are currently being evaluated as part of the Whitney Project. This paper reports on the implementation and performance of a Fast Ethernet network configured in a 4x4 2D torus topology in a testbed cluster of “commodity” Pentium Pro PCs. Several benchmarks were used for performance evaluation: an MPI point to point message passing benchm...

Abstract One of the basic assumptions in hub covering problems is considering the covering radius as an exogenous parameter which cannot be controlled by the decision maker. Practically and in many real world cases with a negligible increase in costs, to increase the covering radii, it is possible to save the costs of establishing additional hub nodes. Change in problem parameters during the pl...

Biological networks are fast becoming a popular tool for modeling high-throughput data, especially due to the ability of the network model to readily identify structures with biological function. However, many networks are fraught with noise or coincidental edges, resulting in signal corruption. Previous work has found that the implementation of network filters can reduce network noise and size...