BACKGROUND Hyperlipidemia animal models have been established, but complete gene expression profiles of the transition from normal lipid levels have not been obtained. Miniature pigs are useful model animals for gene expression studies on dietary-induced hyperlipidemia because they have a similar anatomy and digestive physiology to humans, and blood samples can be obtained from them repeatedly....

Small changes in lipogenic enzyme activity induced by dietary fats of different composition may, over the long term, have significant impact on the development of obesity. We have investigated the effect of high fat diets (45% of calories as fat) on abundance of mRNA encoding fatty acid synthetase (FAS) and glycerophosphate dehydrogenase (GPDH) in male Sprague-Dawley rats. When caloric intake w...

Objective: Several diseases are reported to be uncommon in those parts of the world where dietary fiber intakes are high, therefore, in this study; we evaluated the hypocholesterolemiceffects of a dietary fiber (guar gum) in hypercholesteromic rats. Materials and Methods: Rats were fed high-fat or a normal fed diet for 12-week then treated with 5% guar gum in their regime during a 28 days peri...

Studies in rodents have shown that short-term increases in dietary fat result in fat cell enlargement and insulin resistance. In humans, although high-fat diets have been associated with obesity, little is known about the specific metabolic effects of these diets. In this study we explored possible associations between habitual dietary composition and insulin sensitivity. Twenty-two lean and 23...

T HE correlation between the amount of dietary fat, the concentration of serum cholesterol and the incidence of ischemic heart diseaset is widely accepted as a cause and effect relationship by nutritionists, public health authorities, biochemists, practising physicians and by the public itself. Evidence favoring this correlation has been presented in a large number of epidemiologic studies, amo...

Dietary fat has been widely studied as a risk factor for breast cancer, with little consistency in results. The Multiethnic Cohort Study (MEC) provides an opportunity to assess this relationship for possible heterogeneity across different racial/ethnic groups, as well as by stratification on several other variables associated with risk. Therefore, we investigated the associations between dietar...

background : the excessive changes in serum of lipids, lipoproteins and apolipproteins can be considered as strong risk factors for cardiovascular diseases.in particularlipoproteins can determine the risk of cardiovascular illnesses in teenyears (before showing clinical symptoms).studies have shown that the serum level of ldl c -hdl c is a function of the productionamount of apoa 1 and apob 100...