Abstract Objectives Radiation‐induced rhinosinusitis is a vital dose‐limiting reaction in patients with head and neck malignancy. Unlike oral mucositis during or after radiotherapy, radiation‐induced sinusitis easily overlooked clinical practice rarely included experimental studies. Herein, we review the literature to date on rhinosinusitis. Methods Relevant studies published between 1995 2022 ...

Introduction: Coronary angiography is a Diagnostic-Therapeutic method involving ionizing radiation. This method causes to DNA damage with form double stranded breaks which is followed by the phosphorylation of the histone, H2AX. H2AX is a key factor in the repair process of damaged DNA which will accumulate to damage sites. In human cells, H2AX constitutes about 10% of the H2A ...

Autophagy has recently emerged as a significant mechanism in cancer treatment. Although gemcitabine and/or ionizing radiation are important modalities in the treatment of pancreatic cancer, the contribution of autophagy in such treatment has not been fully elucidated. This study investigated the role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation. To ...

elevated amounts of free radicals due to ionizing radiation have damaging effects on the body. h2-receptor antagonists have potential oxygen radical scavenging properties. we tried to determine the effects of two h2-receptor antagonists (cimetidine and ranitidine) on lipid peroxidation (lpo) and lipid profile (lp) in plasma and liver of γ-irradiated (1gy/day for 3 days) balb/c mice. the control...

The p53 protein is one of the major tumor suppressor proteins. In response to DNA damage, p53 is prevented from degradation and accumulates to high levels. Ionizing radiation leads to hypophosphorylation of the p53 ubiquitin ligase Mdm2 at sites where phosphorylation is critical for p53 degradation and to the phosphorylation and activation of Akt/PKB, a kinase that phosphorylates and inhibits G...

physical agents such as ultraviolet or ionizing radiation and repetitive trauma have been related to the causation of cancer in humans. much less clear is the association between exposure to radiofrequency, such as radar and microwave radiation to the development of cancer. sporadic case reports and small series suggest that this type of radiation might lead to cancer or contribute to its evolu...

1. Hall EJ. Radiobiology for the radiologist. 5th ed. Philadelphia: Lippincott, Wiliams & Wilkins; 2000. 2. Aypar U, Morgan WF, Baulch JE. Radiation-induced genomic instability: are epigenetic mechanisms the missing link? Int J Radiat Biol. 2011;87:179--91. 3. Fliedner TM, Friesecke I, Beyrer K. Medical Management of Radiation Accidents: Manual on the Acute Radiation Syndrome. Oxford: British I...

Introduction: Ionizing radiations are the hazardous agents in the workplace and all forms of ionizing radiation produce some type of injuries. Awareness of application of protection guidelines and knowledge of the principles of radiation protection can play an important role in health of employees. Survey of radiation employee’s levels of awareness and practical behavior is essential and ...

Objective(s): In recent years, the application of radiopharmaceuticals in nuclear medicine has increased substantially. Following the diagnostic procedures performed in nuclear medicine departments, such as myocardial perfusion imaging, patients generally receive considerable doses of radiation. Normally, radiation-induced DNA damages are expected following exposure to a low-dose ionizing radia...

A bystander effect is biological changes in non-irradiated cells by transmitted signals from irradiated bystander cells, which causes the radiation toxic effects on the adjacent non-irradiated tissues. This phenomenon occurs by agents such as ionizing radiation, ultraviolet radiation (UVR) and chemotherapy. The bystander effect includes biological processes such as damage to DNA, cell death, ch...